HOS1 activates DNA repair systems to enhance plant thermotolerance.

Nature Plants
Shin-Hee HanChung-Mo Park

Abstract

Plants possess an astonishing capability of effectively adapting to a wide range of temperatures, ranging from freezing to near-boiling temperatures1,2. Yet, heat is a critical obstacle to plant survival. The deleterious effects of heat shock on cell function include misfolding of cellular proteins, disruption of cytoskeletons and membranes, and disordering of RNA metabolism and genome integrity3-5. Plants stimulate diverse heat shock response pathways in response to abrupt temperature increases. While it is known that stressful high temperatures disturb genome integrity by causing nucleotide modifications and strand breakages or impeding DNA repair6, it is largely unexplored how plants cope with heat-induced DNA damages. Here, we demonstrated that high expression of osmotically reponsive genes 1 (HOS1) induces thermotolerance by activating DNA repair components. Thermotolerance and DNA repair capacity were substantially reduced in HOS1-deficient mutants, in which thermal induction of genes encoding DNA repair systems, such as the DNA helicase RECQ2, was markedly decreased. Notably, HOS1 proteins were thermostabilized in a heat shock factor A1/heat shock protein 90 (HSP90)-dependent manner. Our data indicate that the thermoresp...Continue Reading

References

Oct 28, 1998·Trends in Cell Biology·D H Lee, A L Goldberg
Jun 11, 1999·Plant Physiology·L A Wanner, O Junttila
Nov 1, 2000·Nucleic Acids Research·F HartungH Puchta
Oct 17, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Christian Jantschitsch, Franz Trautinger
Oct 7, 2004·Trends in Plant Science·Ron MittlerFrank Van Breusegem
Jan 31, 2006·The Plant Journal : for Cell and Molecular Biology·Keith W EarleyCraig S Pikaard
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Chun-Hai DongJian-Kang Zhu
Dec 19, 2007·Cell Research·Helena Lobo BorgesJean Y J Wang
Dec 2, 2009·The Plant Journal : for Cell and Molecular Biology·Pil Joon SeoChung-Mo Park
Jan 5, 2010·Trends in Cell Biology·D M ToivolaM B Omary
Oct 23, 2010·Molecular Cell·Séverine BoulonAngus I Lamond
Jan 19, 2011·Plant, Cell & Environment·Hsiang-Chin LiuYee-Yung Charng
Feb 9, 2012·The Plant Journal : for Cell and Molecular Biology·Sangmin LeeChung-Mo Park
May 26, 2012·Current Biology : CB·Amanda J CrawfordKeara A Franklin
Feb 23, 2013·Cell Stress & Chaperones·Andrija Finka, Pierre Goloubinoff
Nov 18, 2014·Nature Communications·Hyo-Jun LeeChung-Mo Park
Jan 27, 2015·The Plant Journal : for Cell and Molecular Biology·Bangshing WangJian-Kang Zhu
Feb 24, 2015·Journal of Experimental Botany·Dana R MacGregor, Steven Penfield
Apr 19, 2017·The New Phytologist·Young-Joon ParkChung-Mo Park

❮ Previous
Next ❯

Citations

Feb 16, 2021·Trends in Plant Science·Young-Joon ParkChung-Mo Park
Nov 18, 2020·Nature Plants·Annika Dorn, Holger Puchta
Apr 4, 2021·International Journal of Molecular Sciences·Aishwarya Kothari, Jennifer Lachowiec
Aug 4, 2021·Journal of Experimental Botany·Shin-Hee HanChung-Mo Park

❮ Previous
Next ❯

Datasets Mentioned

BETA
PRJNA658831

Methods Mentioned

BETA
transgenic
immunoprecipitation
fluorescence complementation
PCR
RNA-seq
electrophoresis
ChIP
transfection
two-hybrid
fluorescence microscopy

Software Mentioned

QuantStudio Real - Time PCR
casplab
MikroWin
Zen
ImageJ
Casp
Fusion Molecular Imaging
Primer Express
cellSens Standard
Biological Networks Gene Ontology tool ( BiNGO )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved