PMID: 3215291Dec 1, 1988Paper

Hospital-acquired infection with methicillin-resistant and methicillin-sensitive staphylococci

Epidemiology and Infection
M R Law, O N Gill

Abstract

In-patients at a London hospital over one year from whom the south-east England strain of 'epidemic' methicillin-resistant Staphylococcus aureus (MRSA) was isolated were compared with in-patients with strains of methicillin-sensitive Staphylococcus aureus (MSSA). MRSA were virtually entirely hospital-acquired; isolates before 10 days were uncommon and related to recent previous admission. Thereafter first isolates occurred at a fairly constant daily rate of about 1.9 per 1,000 in-patients. Acquisition of MSSA after more than 4 days in hospital occurred at a similar constant rate. Such strains were less likely to be penicillin-sensitive than strains isolated in the first 4 days after admission (11 vs. 22%) and were considered to be hospital-acquired. The single MRSA strain caused 40 infections in a year, about half of all hospital-acquired staphylococcal infections. Patients prescribed anti-staphylococcal antibiotics and patients with indwelling cannulae both had about a ninefold increased risk of acquiring MRSA. There was no reciprocal increase in MSSA infections after control measures had substantially reduced the number of MRSA infections.

References

Mar 1, 1986·The Journal of Hospital Infection·M W Casewell
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Jun 1, 1982·American Journal of Epidemiology·C C LinnemannJ L Staneck
Sep 1, 1982·Annals of Internal Medicine·R L ThompsonR P Wenzel

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Citations

May 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·X CorbellaF Gudiol
Jun 6, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Carlene A MutoUNKNOWN SHEA
Aug 5, 2005·Vascular and Endovascular Surgery·Scott E CowieYork N Hsiang
Apr 9, 2001·Critical Care Medicine·M BodiJ Rello
Mar 15, 2002·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Barry M Farr, William R Jarvis
Sep 27, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Thomas P LodiseMichael Rybak
Jul 3, 2014·Biomaterials Science·Ponnurengam Malliappan SivakumarMukesh Doble
Aug 9, 2002·Canadian Journal of Microbiology·Nevio Cimolai
Jan 24, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jonathan D EdgeworthJodi A Lindsay
Aug 30, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Moo Kyun ParkSung Won Chae
Jul 9, 2011·The Journal of Antimicrobial Chemotherapy·Elizabeth MostofskyGili Regev-Yochay
Jan 1, 1990·Society for Applied Bacteriology Symposium Series·B Cookson, I Phillips
Oct 1, 1992·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·R C HershowN L Smith
Mar 5, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alain CombesClaude Gibert

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