Hospital-based surveillance of intussusception among infants

Jornal de pediatria
Eder Gatti FernandesHelena Keico Sato

Abstract

Intussusception surveillance was initiated after the nationwide introduction of live attenuated monovalent rotavirus vaccine (RV1). The objective is to assess the epidemiology of intussusception and compare the number of cases before and after the introduction of rotavirus vaccine. Cases of intussusception occurring between March 2006 and January 2008 were identified through a prospective enhanced passive surveillance system established in sentinel state hospitals. Retrospective review of medical records was used to identify cases, which occurred in sentinel hospitals between January 2001 and February 2006. From 2001 to 2008, 331 intussusception cases were identified, 59.5% were male, with peak incidence among those 18-24 weeks of age. Overall <10% of cases were among infants 6-14 weeks of age (when the first dose of RV1 is administered). The most frequently observed signs or symptoms of intussusception included vomiting (89.4%), bloody stool (75.5%), and abdominal distention (71.8%). A majority (92.1%) of the case-patients required surgery for treatment; 31.8% of those who underwent surgery required bowel resection, and 13 (3.9%) died. Among the 21 hospitals that reported cases throughout the entire surveillance period (2001-2...Continue Reading

References

Feb 24, 2001·The New England Journal of Medicine·T V MurphyUNKNOWN Rotavirus Intussusception Investigation Team
Jan 6, 2006·The New England Journal of Medicine·Guillermo M Ruiz-PalaciosUNKNOWN Human Rotavirus Vaccine Study Group
Jan 6, 2006·The New England Journal of Medicine·Timo VesikariUNKNOWN Rotavirus Efficacy and Safety Trial (REST) Study Team
Oct 3, 2006·The Journal of Pediatrics·Julie E BinesUNKNOWN Intussusception Study Group
Sep 4, 2007·Pediatrics·Michael BuettcherUlrich Heininger
Oct 13, 2009·The Journal of Infectious Diseases·Umesh D ParasharRoger I Glass
Oct 30, 2009·Expert Review of Vaccines·Manish M PatelUmesh D Parashar
Nov 26, 2009·Vaccine·Chowalit KhumjuiChuleeporn Jiraphongsa
Jan 29, 2010·The New England Journal of Medicine·Vesta RichardsonManish Patel
Jun 17, 2011·The New England Journal of Medicine·Manish M PatelUmesh D Parashar
May 2, 2012·Vaccine·A Duncan SteeleUmesh D Parashar
Jun 15, 2012·The Pediatric Infectious Disease Journal·F Raúl VelázquezThomas Verstraeten
Jun 30, 2012·The Lancet Infectious Diseases·Manish M PatelUmesh D Parashar

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Citations

Jan 17, 2021·Indian Journal of Pediatrics·Madhu GuptaNayana P Nair
Nov 17, 2020·The American Journal of Emergency Medicine·Xiao Bing TangYu Zuo Bai

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