Hospital Wastewater as a Reservoir for Antibiotic Resistance Genes: A Meta-Analysis.

Frontiers in Public Health
Shengcen ZhangBin Li

Abstract

Background: The emergence and dissemination of antibiotic resistance genes (ARGs) in the environment poses a huge global health hazard. Hospital wastewater (HWW), in which a high density of antibiotic residues and antibiotic-resistant bacteria are present, may be a reservoir of ARGs dissemination into the environment. Our meta-analysis comprehensively analyzes the prevalence of ARGs in HWW, as well as the influencing factors in ARGs distribution. Methods: Online databases were used to search for literature using the subject terms: "Drug Resistance" AND "Genes" AND "Hospitals" AND "Wastewater." Two reviewers independently applied predefined criteria to assess the literature and extract data including "relative abundance of ARGs," "title," "authors," "country," "location," "sampling year," and "sampling seasons." The median values and 95% confidence intervals of ARGs abundance were calculated by Wilcox.test function in R. Temporal trends, spatial differences, seasonal variations and removal efficiency of ARGs were analyzed by Pearson correlation analysis and Kruskal-Wallis H test. Results: Resistance genes to carbapenems, sulfonamides, tetracyclines and mobile genetic elements were found at high relative abundance (>10-4 gene cop...Continue Reading

References

Oct 31, 2000·Applied and Environmental Microbiology·M T SuzukiE F DeLong
Dec 23, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K Kümmerer, A Henninger
May 11, 2010·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Paola VerlicchiLuigi Masotti
Feb 26, 2013·Ecotoxicology and Environmental Safety·Ewa KorzeniewskaMonika Harnisz
Mar 12, 2013·The Science of the Total Environment·Ana Rita VarelaCélia M Manaia
Oct 25, 2013·The ISME Journal·Thibault StalderMarie-Cécile Ploy
Jun 24, 2014·BioMed Research International·Nassima DjahmiJean-Philippe Lavigne
Mar 31, 2015·Nature Reviews. Microbiology·Thomas U BerendonkJosé Luis Martinez
May 5, 2016·Environmental Science & Technology·Xiang-Zhou MengRolf U Halden
Nov 18, 2016·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Marimuthu Ragavan Ramesh KumarSunil S Solomon
Dec 1, 2014·Journal of Global Antimicrobial Resistance·Carlos Narciso-da-RochaCélia M Manaia
Jan 14, 2017·Environmental Science and Pollution Research International·Jèssica SubiratsCarles M Borrego
Feb 9, 2017·The Journal of Antimicrobial Chemotherapy·Will P M RoweGareth P Pearce
Sep 7, 2017·Environmental Science and Pollution Research International·Marine LaquazYves Perrodin
Sep 28, 2017·Environmental Science & Technology·Manisha LambaS Z Ahammad
Oct 22, 2017·The Science of the Total Environment·Qiang WangQingxiang Yang
Feb 2, 2018·Frontiers in Microbiology·Fateme Barancheshme, Mariya Munir
Apr 14, 2018·Environment International·Yuyi YangWei Xing
Jul 11, 2018·Environment International·Manisha LambaS Z Ahammad

❮ Previous
Next ❯

Software Mentioned

R
EndNote

Related Concepts

Related Feeds

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.