Hospitalisations and outpatient visits for undifferentiated fever attributable to scrub typhus in rural South India: Retrospective cohort and nested case-control study

PLoS Neglected Tropical Diseases
Carol S DevamaniWolf-Peter Schmidt

Abstract

The burden of scrub typhus in endemic areas is poorly understood. This study aimed at estimating the proportion of hospitalisations and outpatient visits for undifferentiated fever in the community that may be attributable to scrub typhus. The study was a retrospective cohort with a nested case-control study conducted in the South Indian state of Tamil Nadu. We conducted house-to-house screening in 48 villages (42965 people, 11964 households) to identify hospitalised or outpatient cases due to undifferentiated fever during the preceding scrub typhus season. We used scrub typhus IgG to determine past infection. We calculated adjusted odds ratios for the association between IgG positivity and case status. Odds ratios were used to estimate population attributable fractions (PAF) indicating the proportion of hospitalised and outpatient fever cases attributable to scrub typhus. We identified 58 cases of hospitalisation and 236 outpatient treatments. 562 people were enrolled as control group to estimate the background IgG sero-prevalence. IgG prevalence was 20.3% in controls, 26.3% in outpatient cases and 43.1% in hospitalised cases. The PAFs suggested that 29.5% of hospitalisations and 6.1% of outpatient cases may have been due to s...Continue Reading

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Citations

Oct 30, 2019·Tropical Medicine & International Health : TM & IH·Wolf-Peter SchmidtJohn A J Prakash
Sep 5, 2021·Journal of Tropical Pediatrics·Vidushi MahajanJagdish Chander
Jan 20, 2022·Future Microbiology·Chandan Kumar ThakurRama Chaudhry

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
ELISA
ELISAs
PCR

Software Mentioned

STATA
R

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