Hospitalised Malaysian children with pandemic (H1N1) 2009 influenza: clinical characteristics, risk factors for severe disease and comparison with the 2002-2007 seasonal influenza

Singapore Medical Journal
Mia Tuang KohSoon Shan Loh

Abstract

The pandemic caused by the H1N1 influenza virus in 2009 resulted in extensive morbidity and mortality worldwide. As the virus was a novel virus, there was limited data available on the clinical effects of the virus on children in Malaysia. Herein, we describe the clinical characteristics of children hospitalised with H1N1 influenza in a tertiary care centre; we also attempted to identify the risk factors associated with disease severity. In this retrospective study, we compared the characteristics of the children who were admitted into the University of Malaya Medical Centre, Malaysia, for H1N1 influenza during the pandemic with those who were admitted for seasonal influenza in 2002-2007. Among the 77 children (aged ≤ 12 years) admitted to the centre due to H1N1 influenza from 1 July 2009-30 June 2010, nearly 60% were aged < 6 years and 40.3% had an underlying medical condition. The top three underlying medical conditions were bronchial asthma (14.3%), cardiac disease (10.4%) and neurological disorder (11.7%). The risk factors for severe disease were age < 2 years, underlying bronchial asthma and chronic lung disease. The three patients who died had a comorbid medical condition. The underlying cause of the deaths was acute resp...Continue Reading

References

Jul 1, 2009·The New England Journal of Medicine·Gerardo ChowellMark A Miller
Oct 10, 2009·The New England Journal of Medicine·Seema JainUNKNOWN 2009 Pandemic Influenza A (H1N1) Virus Hospitalizations Investigation Team
Oct 14, 2009·JAMA : the Journal of the American Medical Association·Guillermo Domínguez-CheritRobert A Fowler
Oct 14, 2009·JAMA : the Journal of the American Medical Association·Anand KumarUNKNOWN Canadian Critical Care Trials Group H1N1 Collaborative
Nov 6, 2009·JAMA : the Journal of the American Medical Association·Janice K LouieUNKNOWN California Pandemic (H1N1) Working Group
Nov 17, 2009·Lancet·V Alberto Laguna-Torres, Jorge Gomez Benavides
Nov 21, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Sean O'RiordanDat Tran
Dec 25, 2009·The New England Journal of Medicine·Janice K LouieUNKNOWN California Pandemic (H1N1) Working Group
Dec 25, 2009·The New England Journal of Medicine·Romina LibsterFernando P Polack
Feb 16, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·I-Ching SamHany Ariffin
Feb 20, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juan Pablo TorresMay Chomalí
Sep 9, 2010·JAMA : the Journal of the American Medical Association·Edward A BelongiaDavid K Shay
Mar 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael A JhungLyn Finelli
Mar 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chad M CoxLyn Finelli
Feb 2, 2013·BMC Infectious Diseases·John J McKennaUNKNOWN 2009 Pandemic Influenza A (H1N1) Virus Hospitalizations Investigation Team

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.