Hospitalizations for coccidioidomycosis at forty-one children's hospitals in the United States

The Pediatric Infectious Disease Journal
Brian T FisherTheoklis E Zaoutis

Abstract

Coccidioidomycosis is often a self-limiting pulmonary infection, but it can cause more clinically apparent disease leading to hospitalization. We describe the characteristics of initial and subsequent hospitalizations in children with coccidioidomycosis. Using the Pediatric Health Information System (PHIS), an inpatient database, we identified retrospectively a cohort of patients hospitalized between April 1, 2002 and June 30, 2007 at children's hospitals across the United States. Demographic, clinical, and therapeutic data for the initial and subsequent hospitalizations were collected and analyzed. We identified 199 children who had 295 hospitalizations for coccidioidomycosis. The median hospital length of stay was 7 days (interquartile range: 3-14 days). Hospital incidence rates were stable from 2003 to 2005 but increased significantly from 2005 to 2006 (8.31/100,000 discharges vs. 12.95/100,000 discharges; chi2 = 4.65, P = 0.031). Fluconazole was the most commonly used antifungal agent, but 17.1% of patients were initially managed without antifungal therapy. The presence of an underlying comorbid condition was common (34.2%) as was the need for surgical intervention (41%). In-hospital mortality was low (1.5%). The increase i...Continue Reading

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Citations

Mar 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James M McCartyJulianne E Hahn
Mar 17, 2011·The Pediatric Infectious Disease Journal·Jennie CollinsDiala Faddoul
Apr 19, 2012·Journal of Pediatric Hematology/oncology·Raquel BravoEmmanuel Katsanis
Mar 1, 2014·Medical Mycology·Emily Whiston, John W Taylor
Feb 26, 2016·Journal of the Pediatric Infectious Diseases Society·Dimana Dimitrova, Lawrence Ross
Jun 25, 2010·Current Fungal Infection Reports·Melissa D Johnson, John R Perfect
Apr 6, 2018·The Pediatric Infectious Disease Journal·Lauren A LeeDuc J Vugia
Nov 19, 2019·The Pediatric Infectious Disease Journal·Fouzia NaeemChokechai Rongkavilit
Oct 16, 2015·The Pediatric Infectious Disease Journal·Gail L SondermeyerDuc J Vugia
Sep 21, 2017·Journal of the Pediatric Infectious Diseases Society·Aspasia KatragkouThomas J Walsh
Jun 18, 2019·The Pediatric Infectious Disease Journal·Daniel K YeohNigel Curtis

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Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

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