Abstract
Coccidioidomycosis is often a self-limiting pulmonary infection, but it can cause more clinically apparent disease leading to hospitalization. We describe the characteristics of initial and subsequent hospitalizations in children with coccidioidomycosis. Using the Pediatric Health Information System (PHIS), an inpatient database, we identified retrospectively a cohort of patients hospitalized between April 1, 2002 and June 30, 2007 at children's hospitals across the United States. Demographic, clinical, and therapeutic data for the initial and subsequent hospitalizations were collected and analyzed. We identified 199 children who had 295 hospitalizations for coccidioidomycosis. The median hospital length of stay was 7 days (interquartile range: 3-14 days). Hospital incidence rates were stable from 2003 to 2005 but increased significantly from 2005 to 2006 (8.31/100,000 discharges vs. 12.95/100,000 discharges; chi2 = 4.65, P = 0.031). Fluconazole was the most commonly used antifungal agent, but 17.1% of patients were initially managed without antifungal therapy. The presence of an underlying comorbid condition was common (34.2%) as was the need for surgical intervention (41%). In-hospital mortality was low (1.5%). The increase i...Continue Reading
References
Mar 1, 1967·The Journal of Pediatrics·H B RichardsonB M McKay
Apr 1, 1967·Archives of Surgery·A R Grant, D W Melick
Mar 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T R Larwood
Nov 18, 2000·Journal of Pediatric Surgery·M B Connelly, J T Zerella
Jun 5, 2001·Pediatrics·C FeudtnerT D Koepsell
Aug 29, 2002·The Journal of Infectious Diseases·Nancy CrumMark Wallace
Mar 21, 2003·International Journal of Biometeorology·Korine N Kolivras, Andrew C Comrie
May 5, 2005·The Journal of Infectious Diseases·Benjamin J ParkRana A Hajjeh
May 24, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gregory M AnsteadJohn R Graybill
Oct 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John N GalgianiUNKNOWN Infectious Diseases Society of America
Feb 16, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jaclyn H ChuTheoklis E Zaoutis
Mar 10, 2007·Annals of the New York Academy of Sciences·Jorge TalamantesCharles S Zender
May 22, 2007·Annals of the New York Academy of Sciences·Rebecca H SunenshineKenneth Komatsu
Jun 28, 2007·JAMA : the Journal of the American Medical Association·Chris FeudtnerTammy I Kang
Aug 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Antonino CatanzaroJohn N Galgiani
May 8, 2008·JAMA : the Journal of the American Medical Association·Jillian MongelluzzoSamir S Shah
Jan 28, 2009·Pediatrics·Theoklis ZaoutisRon Keren
May 26, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeffrey S GerberTheoklis E Zaoutis
Citations
Mar 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James M McCartyJulianne E Hahn
Mar 17, 2011·The Pediatric Infectious Disease Journal·Jennie CollinsDiala Faddoul
Feb 25, 2011·The Pediatric Infectious Disease Journal·David SiegelNalini Singh
Apr 19, 2012·Journal of Pediatric Hematology/oncology·Raquel BravoEmmanuel Katsanis
Aug 23, 2012·PloS One·Emily WhistonJohn W Taylor
Mar 1, 2014·Medical Mycology·Emily Whiston, John W Taylor
Feb 26, 2016·Journal of the Pediatric Infectious Diseases Society·Dimana Dimitrova, Lawrence Ross
Jun 25, 2010·Current Fungal Infection Reports·Melissa D Johnson, John R Perfect
Apr 6, 2018·The Pediatric Infectious Disease Journal·Lauren A LeeDuc J Vugia
Mar 30, 2019·Hospital Pediatrics·Kara A BjurYoung J Juhn
Nov 19, 2019·The Pediatric Infectious Disease Journal·Fouzia NaeemChokechai Rongkavilit
Oct 16, 2015·The Pediatric Infectious Disease Journal·Gail L SondermeyerDuc J Vugia
Sep 21, 2017·Journal of the Pediatric Infectious Diseases Society·Aspasia KatragkouThomas J Walsh
Jun 18, 2019·The Pediatric Infectious Disease Journal·Daniel K YeohNigel Curtis
Jan 1, 2015·Healthcare·Erin Mary Gaab, Fouzia Naeem