Hospitalized cancer patients with acquired long QT syndrome-a matched case-control study

Cardio-Oncology
Yajuan LinYunlong Xia

Abstract

Our recent study has revealed that many hospitalized patients with acquired long QT syndrome (ALQTS) are cancer patients. This study aims to determine the risk factors and outcomes of hospitalized cancer patients with ALQTS. We performed a matched case-control study within a cohort of 10,180 cancer patients hospitalized between September 2013 and April 2016. Among them, 150 patients defined as having severe ALQTS with a markedly prolonged QT interval (QTc ≥ 500 ms) were compared with 293 age-, sex- and cancer-type-matched controls (non-ALQTS). Death as the endpoint was followed for up to 2 years. Cox regression and Kaplan-Meier survival analyses were performed to assess the effects of particular clinical variables on all-cause mortality. Multivariate logistic regression was performed to calculate odds ratios (OR) for various predictors of QT prolongation. The mortality was significantly higher in ALQTS group (63.3% vs. 33.4%). Hypertension, hypokalemia, hypocalcemia, QT-prolonging drugs, infection, anemia, anti-microtubule agents were contributing factors to ALQTS. Renal insufficiency, male gender and hypokalemia were found to be independent risk factors for all-cause mortality in ALQTS group. Markedly prolonged QT interval was...Continue Reading

References

Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Barry LondonGuy Salama
Sep 27, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean T BarbeySteven L Soignet
Dec 13, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Polina S Petkova-KirovaGuy Salama
Mar 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·María Fernández-VelascoCarmen Delgado
Aug 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth L StrevelLillian L Siu
Oct 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Manuela SchmidingerHerwig Schmidinger
Feb 21, 2009·Pediatric Blood & Cancer·Robert I LiemAlexis A Thompson
Jun 13, 2009·Journal of the American College of Cardiology·Edward T H Yeh, Courtney L Bickford
Aug 26, 2009·British Journal of Pharmacology·Joffrey DucroqM Le Grand
Jan 13, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Samuel A WellsMartin Schlumberger
Oct 4, 2011·Journal of Pharmacy & Bioallied Sciences·Ioana Mozos, Corina Serban
Jun 16, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelElizabeth Ward
Dec 13, 2012·Journal of Cardiovascular Disease Research·Adeseye A AkintundeOladimeji G Opadijo
Mar 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayF Bray
Apr 2, 2013·Mayo Clinic Proceedings·Kristina H HaugaaMichael J Ackerman
Apr 27, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Rashmi R ShahDevron R Shah
Apr 30, 2013·European Journal of Haematology·Bharathi UpadhyaMary Ann Knovich
Jan 13, 2015·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Juan TamargoEva Delpón
Aug 21, 2015·Nature Reviews. Cardiology·Michael S Ewer, Steven M Ewer
Dec 17, 2015·Chinese Medical Journal·Yu-Dong FeiLi Zhang
Mar 23, 2017·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Haixu YuYunlong Xia

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

QTc
Muse System
Pro
SPSS

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Haixu YuYunlong Xia
Postgraduate Medical Journal
Sérgio BarraRui Providência
Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Aimée D C PaulussenJeroen Aerssens
© 2021 Meta ULC. All rights reserved