Host afferents into intrastriatal transplants of fetal ventral mesencephalon.

Experimental Neurology
G DoucetA Björklund

Abstract

Host afferents into fetal ventral mesencephalic tissue grafted to the neostriatum of adult rats have been studied by using anterograde transport of Phaseolus vulgaris leucoagglutinin (PHA-L) and immunocytochemistry for serotonin (5-HT), Substance P (SP), and dopamine-adenosine 3':5'-monophosphate-regulated-phosphoprotein-32 (DARPP-32). Numerous fibers of cortical origin were detected in the transplants following multiple (11-15) iontophoretic injections of PHA-L into the frontal and anterior cingulate cortex. The labeled fibers occurred with an apparently random distribution throughout the graft tissue. Their overall density was lower than that of the surrounding striatum but similar to that found in the host nigra-ventral tegmental area. The majority of the PHA-L-labeled fibers in the grafts were thin and tortuous with varicosities or lateral clubs with terminal boutons. Dual labeling showed frequent close appositions between PHA-L-labeled terminals and dopamine-immunoreactive cell bodies. In parallel electron microscopy, synaptic contacts were observed between PHA-L-labeled terminals and unlabeled neuronal profiles in the graft. Other labeled fibers in the grafts were thick and smooth, corresponding probably to labeled myelin...Continue Reading

References

Nov 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A I LeveyB H Wainer
Jul 1, 1985·The Journal of Comparative Neurology·R B GibbsC W Cotman
Aug 1, 1987·Journal of Neurochemistry·J L ChagnaudM Geffard
Aug 15, 1988·The Journal of Comparative Neurology·M Peschanski, O Isacson
May 15, 1986·The Journal of Comparative Neurology·P J ReierJ R Wujek
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jul 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A BerodJ F Pujol
Jan 1, 1989·The European Journal of Neuroscience·José Angel ArmengolRosa-Magda Alvarado-Mallart

❮ Previous
Next ❯

Citations

Sep 1, 1994·Progress in Neurobiology·J P Herman, N D Abrous
Mar 11, 2004·The International Journal of Biochemistry & Cell Biology·Rowan M BurnsteinMaeve A Caldwell
Aug 23, 2005·Brain Research. Brain Research Reviews·Emilio Fernandez-EspejoSusana Ramiro
Mar 31, 2010·Journal of Applied Measurement·Ulrich Müller, Willis F Overton
Sep 5, 2008·Nature Reviews. Neuroscience·Patrik BrundinTamas Revesz
Oct 31, 2013·Proceedings of the National Academy of Sciences of the United States of America·Daniella RylanderBarbara Picconi
Jan 22, 2009·Médecine sciences : M/S·Faustine Lelan, Philippe Damier
Feb 24, 2016·Frontiers in Cellular Neuroscience·Daniella Rylander Ottosson, Emma Lane
Jul 21, 2009·Neurobiology of Disease·Afsaneh GaillardMohamed Jaber
Jul 1, 2008·Progress in Neurobiology·Tomas DeierborgPatrik Brundin
Jan 8, 2009·Annals of Neurology·Ole Isacson, Jeffrey H Kordower
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·D F EmerichP R Sanberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.