Host and environmental factors influencing respiratory secretion of pro-wheezing biomarkers in preterm children

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
Vanesa MatíasJesus F Bermejo-Martin

Abstract

Cytokines are actively secreted by the respiratory mucosa of preterm children and participate in the pathogenesis of wheezing. This study aimed to identify the factors that could potentially influence respiratory secretion of cytokines in these children. A nasopharyngeal aspirate (NPA) was collected from 77 preterm children 1 yr after birth. NPAs from 14 healthy, 1-yr-old term children were collected in parallel. 27 cytokines were measured in the NPAs using a multiplex assay. Multivariate stepwise regression analysis with Bonferroni correction evidenced that the variable [daycare attendance] was associated with higher levels of [monocyte chemoattractant protein-1 (MCP-1), IL-6, vascular endothelial growth factor (VEGF), IL-1β, IL-10, tumor necrosis factor (TNF)-α]; [male sex] with higher levels of (MCP-1, VEGF, and IL-1β); [smokers at home] was associated with higher levels of MCP-1 (p < 0.0013). In turn, [prophylaxis with palivizumab] was associated with lower levels of (IL-6, IL-7) (p < 0.0013). All these mediators participate in the pathogenesis of asthma and recurrent wheezing. Preterm children secreted higher levels of chemokines (interferon-gamma inducible protein-10, macrophage inflammatory protein-1α, Eotaxin, MCP-1), g...Continue Reading

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Citations

Dec 25, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Agnes M M Sonnenschein-van der VoortLiesbeth Duijts
Sep 12, 2012·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Laura San FelicianoJesus F Bermejo-Martin
Dec 5, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Håvard TrønnesDag Moster
Feb 18, 2014·The Journal of Allergy and Clinical Immunology·Agnes M M Sonnenschein-van der VoortLiesbeth Duijts
Dec 30, 2014·European Journal of Epidemiology·Liesbeth DuijtsJohan C de Jongste
Apr 30, 2016·Allergy, Asthma & Immunology Research·Woo Sung ChangJoo Shil Lee
Mar 27, 2021·European Journal of Pediatrics·Ian Henderson, Siobhan Quenby

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