Host and Microbial Tryptophan Metabolic Profiling in Multiple Sclerosis.

Frontiers in Immunology
Lorenzo GaetaniTeresa Zelante

Abstract

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that is associated with demyelination and neuronal loss. Over recent years, the immunological and neuronal effects of tryptophan (Trp) metabolites have been largely investigated, leading to the hypothesis that these compounds and the related enzymes are possibly involved in the pathophysiology of MS. Specifically, the kynurenine pathway of Trp metabolism is responsible for the synthesis of intermediate products with potential immunological and neuronal effects. More recently, Trp metabolites, originating also from the host microbiome, have been identified in MS, and it has been shown that they are differently regulated in MS patients. Here, we sought to discuss whether, in MS patients, a specific urinary signature of host/microbiome Trp metabolism can be potentially identified so as to select novel biomarkers and guide toward the identification of specific metabolic pathways as drug targets in MS.

References

Jul 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·F MonacoR Mutani
Jun 9, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Erik KwidzinskiIngo Bechmann
Oct 18, 2006·Clinical and Experimental Pharmacology & Physiology·Caroline M ForrestL Gail Darlington
Sep 4, 2007·Nature Reviews. Immunology·Paolo Puccetti, Ursula Grohmann
Sep 26, 2007·The European Journal of Neuroscience·L G DarlingtonT W Stone
Oct 16, 2007·Journal of Neuroimmunology·Anne L Astier, David A Hafler
Jul 20, 2010·Immunological Reviews·Ursula Grohmann, Vincenzo Bronte
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Jan 1, 2010·International Journal of Tryptophan Research : IJTR·L Gail DarlingtonTrevor W Stone
Dec 29, 2012·Beneficial Microbes·K Tsilingiri, M Rescigno
Feb 2, 2013·ACS Chemical Biology·Teklab GebregiworgisRobert Powers
Jan 21, 2014·Annual Review of Immunology·Lawrence Steinman
Mar 17, 2015·Lancet Neurology·Anthony FeinsteinAlbert C Lo
Apr 1, 2012·Multiple Sclerosis and Related Disorders·Ruth Dobson
Aug 8, 2015·Nature Reviews. Immunology·Calliope A DendrouManuel A Friese
Aug 20, 2016·Frontiers in Immunology·Michael D LovelaceBruce J Brew
Nov 1, 2016·Brain : a Journal of Neurology·Jorge CorrealeMarcela P Fiol
May 27, 2017·Experimental & Molecular Medicine·Donghyun KimGabriel Núñez
Jan 19, 2018·Immunity·Cristina Gutiérrez-Vázquez, Francisco J Quintana
May 18, 2018·Nature·Veit RothhammerFrancisco J Quintana
Oct 14, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·J SinghShailendra Giri
Nov 24, 2018·Nature Reviews. Disease Primers·Massimo FilippiMaria A Rocca
Jun 19, 2019·American Journal of Physiology. Endocrinology and Metabolism·Vivek Krishna Pulakazhi VenuSimon A Hirota
Aug 9, 2019·Annals of Clinical and Translational Neurology·Emmanuelle WaubantAnnette Langer-Gould
Aug 10, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Adam FambiatosTomas Kalincik
Sep 8, 2019·Probiotics and Antimicrobial Proteins·Alexander V Oleskin, Boris A Shenderov

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Citations

Sep 25, 2020·Journal of Clinical Medicine·Remsha AfzalClaire E McCoy
Aug 28, 2020·Frontiers in Immunology·Josephine BrownLaurence Morel
Jan 16, 2021·Cellular and Molecular Life Sciences : CMLS·Insha ZahoorShailendra Giri
Dec 29, 2020·Neurology. Neuroimmunology and Neuroinflammation·Thanos TsaktanisVeit Rothhammer
Mar 5, 2021·Cytokine & Growth Factor Reviews·Xavier Dagenais-LussierJulien van Grevenynghe
Apr 4, 2021·International Journal of Molecular Sciences·Sameeksha ChopraAntoine Dufour
May 22, 2021·Journal of Neuroendocrinology·Savani Anbalagan
Jul 25, 2021·Neurology. Neuroimmunology and Neuroinflammation·Ana CiracVeit Rothhammer
Aug 20, 2021·Annals of Clinical and Translational Neurology·Mary K HortonUNKNOWN U.S. Network of Pediatric MS Centers

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Methods Mentioned

BETA
urine sampling

Software Mentioned

SPSS Statistics

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