Host and tumour factors in cancer metastasis

European Journal of Clinical Investigation
I J Fidler

Abstract

The process of cancer metastasis is sequential and selective and contains stochastic elements. The growth of metastases represents the endpoint of many lethal events that only few tumour cells survive. Primary tumours contain cells with heterogeneous metastatic properties, and the outcome of metastasis depends on the interplay of tumour cells with various host factors. Collectively, then, our studies and most data reported by others have led us to conclude that metastasis is a highly selective process regulated by a number of mechanisms. This belief is contrary to the once widely accepted notion that neoplastic dissemination is the ultimate expression of cellular anarchy. In fact, suggesting that cancer metastasis is a selective process is a more optimistic view in terms of cancer therapy than the one that contends that tumour dissemination is an entirely random event. A selective biological process is regulated by the interaction of tumour cells with their host, and these complex interactions can be studied and manipulated. A better understanding of the complexity of the processes of tumour evolution, progression, and metastasis should lead to improvements in the treatment of cancer.

References

Sep 1, 1979·Journal of the National Cancer Institute·M L Kripke
Jan 1, 1978·Advances in Cancer Research·I J FidlerI R Hart
Jan 1, 1979·Current Problems in Cancer·E V Sugarbaker
Jun 1, 1978·Journal of the National Cancer Institute·E B Briles, S Kornfeld
Jan 1, 1979·Journal of Supramolecular Structure·K W Brunson, G L Nicolson
Jun 1, 1977·Journal of the National Cancer Institute·I J Fidler, G L Nicolson
Nov 1, 1976·Journal of the National Cancer Institute·I J Fidler, G L Nicolson
Mar 1, 1975·Cancer Treatment Reviews·A J Salsbury
Apr 15, 1988·International Journal of Cancer. Journal International Du Cancer·G Schackert, I J Fidler
Jan 1, 1987·Journal of the National Cancer Institute·F N HuT C Hsu
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R S KerbelM L Breitman
Mar 1, 1987·Current Problems in Surgery·I J Fidler, C M Balch
Apr 1, 1987·Clinical & Experimental Metastasis·S NaitoI J Fidler
Aug 15, 1986·International Journal of Cancer. Journal International Du Cancer·G L Nicolson, K M Dulski
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L WeissM Angelova
Jan 1, 1985·Cancer Metastasis Reviews·C L Reading, J T Hutchins
Feb 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D L Dexter, J T Leith
Sep 1, 1985·The Journal of Cell Biology·P A Netland, B R Zetter
Aug 1, 1971·Annals of Surgery·E V SugarbakerA S Ketcham
Jan 1, 1981·Advances in Cancer Research·M L Kripke
Jan 1, 1983·Cancer Metastasis Reviews·G H Heppner, B E Miller
Jan 1, 1982·Cancer Metastasis Reviews·I R Hart
Jan 1, 1982·Cancer Metastasis Reviews·G Poste
Aug 1, 1983·The British Journal of Surgery·R G SouterM G Kettlewell
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G PosteI J Fidler
Jul 23, 1982·Science·J E TalmadgeI J Fidler
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G PosteI Zeidman
Jan 10, 1980·Nature·G Poste, I J Fidler
Jan 1, 1982·Cancer Metastasis Reviews·N Hanna
Mar 15, 1981·International Journal of Cancer. Journal International Du Cancer·P Frost, R S Kerbel
Nov 1, 1943·Genetics·S E Luria, M Delbrück

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Citations

Sep 1, 1992·Clinical & Experimental Metastasis·Y YoshidaK Sugimachi
Nov 1, 1995·Clinical & Experimental Metastasis·T UdagawaB W McIntyre
Feb 26, 1999·Journal of the National Cancer Institute·H M KooG F Vande Woude
Aug 24, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alessandro AllegraMichele Buemi
Jun 20, 2014·Nature Reviews. Cancer·Marion de JongWytske M van Weerden
Feb 1, 2006·Molecular Aspects of Medicine·Stephen A Bustin, Reinhold Mueller
Mar 19, 1999·Japanese Journal of Cancer Research : Gann·H KikkawaN Oku
Nov 23, 2012·Molecular & Cellular Proteomics : MCP·Mark A MarzinkeHui Zhang
Jul 3, 1998·International Journal of Cancer. Journal International Du Cancer·A TreisterI P Witz
Jan 1, 2010·Cancers·William E DamskyMarcus Bosenberg
Mar 1, 1994·Medicinal Research Reviews·D CoxK Yoshida
Jun 5, 2003·Expert Opinion on Therapeutic Targets·Barbara Fingleton

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