Host and viral RNA-binding proteins involved in membrane targeting, replication and intercellular movement of plant RNA virus genomes

Frontiers in Plant Science
Kiwamu HyodoTetsuro Okuno

Abstract

Many plant viruses have positive-strand RNA [(+)RNA] as their genome. Therefore, it is not surprising that RNA-binding proteins (RBPs) play important roles during (+)RNA virus infection in host plants. Increasing evidence demonstrates that viral and host RBPs play critical roles in multiple steps of the viral life cycle, including translation and replication of viral genomic RNAs, and their intra- and intercellular movement. Although studies focusing on the RNA-binding activities of viral and host proteins, and their associations with membrane targeting, and intercellular movement of viral genomes have been limited to a few viruses, these studies have provided important insights into the molecular mechanisms underlying the replication and movement of viral genomic RNAs. In this review, we briefly overview the currently defined roles of viral and host RBPs whose RNA-binding activity have been confirmed experimentally in association with their membrane targeting, and intercellular movement of plant RNA virus genomes.

References

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Feb 6, 2017·Proceedings of the National Academy of Sciences of the United States of America·Kiwamu HyodoTetsuro Okuno

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Related Concepts

Genome
RNA Virus Infections
Genomics
Plant Viruses
Binding Activity [MoA]
RNA-Binding Proteins
Viral Genome
Viral Life Cycle
RNA

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