Host antigens and parasite antigens of murine Schistosoma mansoni

Transactions of the Royal Society of Tropical Medicine and Hygiene
O L GoldringD J McLaren


An indirect fluorescent antibody technique was used to detect mouse host antigens and parasite antigens on the surface of Schistosoma mansoni. A rabbit anti-mouse rbc antiserum to detect host antigens, and serum from mice immune to S. mansoni was used to detect parasite antigens. Schistosomula prepared after penetration of isolated mouse skin did not possess host antigens but bound antibody from immune serum (immune antibody); schistosomula recovered from the lungs of mice five days after infection possessed host antigens and failed to bind immune antibody. In contrast, schistosomula recovered from the skin of normal or immune mice three and 20 hours after cercarial penetration, adult worms, and cryostat sections of adult worms, were positive for host antigens but also bound immune antibody. Strong binding of immune antibody only occurred with the cryostat sections. Anti-schistosome antibody can therefore bind to schistosomes in the presence of host antigen. The lung forms of schistosomula however, may have different surface properties as there is no evidence that immune antibody binds to these forms.


Sep 1, 1976·Southern Medical Journal·J R Hampton
Jan 1, 1976·Transactions of the Royal Society of Tropical Medicine and Hygiene·N WeissA Degrémont
Feb 26, 1974·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J E Castro
Feb 25, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S R SmithersD J Hockley
Mar 1, 1972·International Journal for Parasitology·J A CLEGG, S R Smithers
Apr 1, 1965·Experimental Parasitology·J A CLEGG


Feb 1, 1987·International Journal for Parasitology·S R Smithers
Apr 1, 1984·Molecular and Biochemical Parasitology·M Nascimento CordeiroE Alvarenga Figueiredo
Nov 1, 1986·Molecular and Biochemical Parasitology·J F ParraT A Mota-Santos
Jan 15, 1987·Molecular and Biochemical Parasitology·M V Rogers, D J McLaren
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·L Q Vieira, J R Kusel
Dec 1, 1984·Parasitology·G C Coles
Aug 1, 1984·Parasitology·D J McLaren
Aug 21, 2009·Parasitology·Paul Hagan
Aug 1, 1982·The Journal of Cell Biology·J C SamuelsonJ R David
Aug 19, 2006·Parasite Immunology·C ThorsE Linder
Mar 1, 1987·Parasite Immunology·K R Rasmussen, W M Kemp
Jan 1, 1982·Immunological Reviews·A E ButterworthE Wells
Mar 1, 1982·Parasite Immunology·A Sher, D Benno
Mar 1, 1982·Parasite Immunology·D J McLaren, R J Terry
Nov 18, 2006·Parasitology·G N GobertD P McManus
Jan 1, 1979·Parasite Immunology·K L TrangleS D Douglas

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