Host antitumor resistance improved by the macrophage polarization in a chimera model of patients with HCC

Oncoimmunology
Akira AsaiFujio Suzuki

Abstract

Despite major advances in curative and palliative approaches, hepatocellular carcinoma (HCC) is still the third leading cause of cancer-related death worldwide. M1 macrophages (Mϕ) play a key role in host antitumor defenses in HCC. In our study, CD14+ cells were isolated from the peripheral blood of four groups of HCC patients (group-1, patients with stage 0 HCC; group-2, patients with stage A HCC; group-3, patients with stage B HCC; and group-4, patients with stage C HCC) and characterized phenotypically. Then, CD14+ cells from group-2 and group-3 HCC patients were induced to polarize and tested for their antitumor abilities in a chimera model of HCC patients. Human HCCs (HepG2 solid tumors) grew in a chimera model of group-3 patients (group-3 HCC chimeras) but not in a chimera model of group-2 patients (group-2 HCC chimeras). In response to HCC antigens, the majority of CD14+ cells from group-2 patients (group-2 CD14+ cells) switched to the M1 phenotype (IL-12+IL-10-iNOS+cells), whereas the majority of CD14+ cells from group-3 patients (group-3 CD14+ cells) did not switch to the M1 phenotype and continued to express M2b phenotypic properties (IL-12-IL-10+CCL1+iNOS-cells). Group-3 CD14+ cells showed M1Mϕ polarization after tre...Continue Reading

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Citations

Dec 24, 2018·Journal of Leukocyte Biology·Le-Xun WangJiao Guo
Jul 25, 2019·Cancer Immunology, Immunotherapy : CII·Meng-Xin TianYing-Hong Shi
Nov 22, 2019·Frontiers in Immunology·Ruibing YangXi Sun
Apr 25, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Erin BresnahanAmaia Lujambio
Mar 7, 2021·Trends in Cancer·Valentina LeoneMathias Heikenwalder

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Methods Mentioned

BETA
antisense oligodeoxynucleotide
X-ray
flow cytometry
ELISA
biopsies
density gradient centrifugation
fluorescence microscopy

Software Mentioned

FlowJo
JMP Pro
CFX Manager

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