Host cell factor 1 inhibits SKN-1 to modulate oxidative stress responses in Caenorhabditis elegans.

Aging Cell
Gizem RizkiSiu Sylvia Lee

Abstract

Host cell factor-1 (HCF-1) is a conserved regulator of the longevity and stress response functions of DAF-16/FOXO. SKN-1 transcription factor is an evolutionarily conserved xenobiotic stress regulator and a pro-longevity factor. Here, we demonstrate that SKN-1 contributes to the enhanced oxidative stress resistance incurred by hcf-1 mutation in C. elegans. HCF-1 prevents the nuclear accumulation of SKN-1 and represses the transcriptional activation of SKN-1 specifically at target genes involved in cellular detoxification pathways. Our findings reveal a novel and context-specific regulatory relationship between two highly conserved longevity and stress response factors HCF-1 and SKN-1.

References

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Citations

Aug 2, 2015·Free Radical Biology & Medicine·T Keith BlackwellMeltem Isik
Aug 8, 2014·Oxidative Medicine and Cellular Longevity·María Elena SotoIsrael Pérez-Torres
Sep 24, 2015·Molecular & Cellular Proteomics : MCP·Timothy W RhoadsJoshua J Coon

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