Host cell invasion by the apicomplexans: the significance of microneme protein proteolysis

Current Opinion in Microbiology
Timothy J Dowse, Dominique Soldati

Abstract

Intracellular life-style has been adopted by many pathogens as a successful immune evasion mechanism. To gain entry to a large variety of host cells and to establish an intracellular niche, Toxoplasma gondii and other apicomplexans rely on an active process distinct from phagocytosis. Calcium-regulated secretion of microneme proteins and parasite actin polymerization together with the action of at least one myosin motor act in concert to generate the gliding motility necessary to propel the parasite into host cells. During this active penetration, host cell transmembrane proteins are excluded from the forming parasitophorous vacuole hence conferring the resistance to acidification and degradative fusion. Apicomplexans possess a large repertoire of microneme proteins that contribute to invasion, but their precise role and the level of functional redundancy remain to be evaluated. Remarkably, most microneme proteins are proteolytically cleaved during biogenesis and post-exocytosis. The significance of the processing events and the identification of the proteases implicated are the object of intensive investigations. These proteases may constitute potential drug targets for intervention against malaria and other diseases caused by...Continue Reading

References

Aug 1, 1991·Molecular and Biochemical Parasitology·A AchbarouJ F Dubremetz
Jul 1, 1994·The Journal of Experimental Medicine·M J BlackmanA A Holder
Jan 31, 1998·Molecular Microbiology·J M DobrowolskiL D Sibley
Aug 29, 1998·The Journal of Biological Chemistry·M J BlackmanF Hackett
Feb 23, 1999·Molecular Microbiology·V B Carruthers, L D Sibley
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·J C BaraleG Langsley
May 29, 1999·Antimicrobial Agents and Chemotherapy·V ConseilJ F Dubremetz
Nov 7, 1999·Molecular and Biochemical Parasitology·F HackettM J Blackman
Sep 21, 2000·International Journal for Parasitology·L JeanP Péry
Oct 29, 2000·The Journal of Biological Chemistry·S BrechtD Soldati
Jan 23, 2001·The Journal of Biological Chemistry·H KieschnickC Beckers
Feb 24, 2001·Cellular Microbiology·V B CarruthersL D Sibley
Jul 12, 2001·Glycobiology·E V LourençoA Panunto-Castelo
Sep 21, 2001·The Journal of Biological Chemistry·S A MillerK Kim
Nov 22, 2001·The Biochemical Journal·P S SijwaliP J Rosenthal
Jan 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ritu BanerjeeDaniel E Goldberg
Jan 22, 2002·Acta Tropica·Vern B Carruthers
Nov 20, 2002·Infection and Immunity·Mingqi DengMitchell S Abrahamsen
Dec 10, 2002·The Journal of Biological Chemistry·Fabien BrossierL David Sibley
Apr 11, 2003·The Journal of Biological Chemistry·Steven A HowellMichael J Blackman
May 24, 2003·The Journal of Biological Chemistry·Letitia JeanMichael J Blackman

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Citations

Nov 1, 2013·Parasitology Research·Akram Ahmed SalamaIkuo Igarashi
Jul 9, 2005·The Journal of Biological Chemistry·Xing W ZhouVern B Carruthers
Apr 14, 2009·Genome Research·James WasmuthJohn Parkinson
Dec 6, 2006·Antimicrobial Agents and Chemotherapy·Chin Fen TeoVern B Carruthers
Jan 27, 2009·Eukaryotic Cell·Jane W WanyiriHonorine D Ward
Nov 8, 2006·Malaria Journal·Roberto Lanzillotti, Theresa L Coetzer
Nov 17, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Atle MysterudNils Chr Stenseth
Feb 7, 2012·Journal of Immunological Methods·Satish MishraVictor Nussenzweig
May 1, 2010·International Journal for Parasitology·Nikolas FriedrichDominique Soldati-Favre
May 19, 2010·International Journal for Parasitology·Eric HanssenLeann Tilley
May 22, 2007·Parasitology International·Photini Sinnis, Alida Coppi
Feb 8, 2005·Molecular and Biochemical Parasitology·M LabbéP Péry
Nov 4, 2004·Trends in Parasitology·Dominique SoldatiAlan F Cowman
Mar 7, 2006·Veterinary Parasitology·David S LindsaySharon G Witonsky
Nov 4, 2005·Molecular and Biochemical Parasitology·Jan HartmannGraham Warren
Jun 1, 2005·Trends in Parasitology·Timothy J Dowse, Dominique Soldati
May 26, 2005·International Journal for Parasitology·Timothy J DowseDominique Soldati
Jul 22, 2015·Parasites & Vectors·Yanhua Wang, Hong Yin
Jun 15, 2007·Veterinary Parasitology·Lucio Ayres CaldasMárcia Attias
Mar 31, 2012·Virulence·Sabrina M FeustelOliver Liesenfeld
Nov 28, 2007·Annual Review of Pathology·James H McKerrowMohammed Sajid
Jan 29, 2017·Experimental Parasitology·Jing WangJing Liu
Feb 14, 2018·Traffic·Olivia L McGovernVern B Carruthers
Feb 23, 2019·Cellular Microbiology·David J Dubois, Dominique Soldati-Favre
Jan 1, 2017·Parasitology Research·Xiaoxia JinJianhua Li

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