Host cell mobilization for in situ tissue regeneration

Rejuvenation Research
Sang Jin LeeJames J Yoo

Abstract

Although small, localized injuries can be healed through the body's normal reparative process, large traumatic injury overwhelms this system and may result in a deficit of functional recovery, despite the use of conventional reconstructive modalities. Cell-based approaches using tissue engineering and regenerative medicine techniques have offered new opportunities for treatment. Although the fundamental principles of cell-based therapies have been demonstrated clinically on multiple tissue systems, usually a donor tissue biopsy and ex vivo cell manipulation prior to implantation in vivo are necessary. The goal of the present study was to investigate whether host biologic resources and environmental conditions could be used for in situ tissue regeneration, which may eliminate the need for donor cell procurement and subsequent in vitro cell manipulation. To address this aim, we implanted a common biomaterial into mice and characterized the infiltrating cells to determine their regenerative potential. We showed that host cell infiltrates are not entirely comprised of inflammatory and fibroblast-like cells and the normal inflammatory process can be altered by incorporating anti-inflammatory agents that influence the formation of sc...Continue Reading

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Citations

Oct 27, 2009·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·J H CheF J Qu
Nov 16, 2013·Experimental & Molecular Medicine·In Kap KoJames J Yoo
Jan 1, 2010·Rejuvenation Research·Aubrey D N J de Grey
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Jun 24, 2014·Acta Biomaterialia·Young Min JuSang Jin Lee
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Jan 31, 2018·Stem Cells Translational Medicine·Sang Jin LeeJames J Yoo
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Oct 19, 2019·Tissue Engineering and Regenerative Medicine·Chengeng YangHak Soo Choi
Jan 16, 2020·Materials·Haowen KwanWasim S Khan
Mar 26, 2021·Frontiers in Cell and Developmental Biology·Jiqiao YangQing Lv

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