PMID: 7543582Sep 1, 1995Paper

Host cell requirements for efficient infection of quiescent primary B lymphocytes by Epstein-Barr virus

Journal of Virology
A J Sinclair, P J Farrell

Abstract

Quiescent primary B lymphocytes are efficiently immortalized by Epstein-Barr virus (EBV). This process requires both the delivery and expression of the viral genome and results in activation of the cell division cycle. Infection of B lymphocytes depends on a direct interaction between the viral glycoprotein gp340/220 and CD21, the C3dg complement receptor. This interaction is required for the adsorption of EBV. In addition, several lines of evidence suggest that the interaction of EBV with CD21 modulates the phenotype of cells. CD21 forms part of a multimeric signal transduction complex with CD19, TAPA-1, and Leu-13. In normal B lymphocytes, CD19 becomes tyrosine phosphorylated following stimulation of the antigen receptor and recruits the signal-transducing enzyme phosphatidylinositol 3-kinase kinase. Here, we investigated the involvement of signal transduction pathways in efficient infection. Protein synthesis is not required for events leading to the transcription of the viral genome, suggesting that the early stages of infection do not depend on the expression of novel cell genes and consistent with the Wp promoter being the first viral promoter used upon infection. Since the stimulation of cells with gp340/220 leads to an ...Continue Reading

References

Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M WoisetschlaegerS H Speck
Jul 1, 1989·The Journal of General Virology·M J AlldayB E Griffin
Nov 1, 1987·Journal of Virology·M BodescotP J Farrell
Dec 1, 1988·The Journal of Experimental Medicine·E A Hurley, D A Thorley-Lawson
Jul 1, 1985·The Journal of Experimental Medicine·D A Thorley-Lawson, K P Mann
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S H SpeckJ L Strominger
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J SampleE Kieff
Feb 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·G MillerM Lipman
Nov 15, 1968·International Journal of Cancer. Journal International Du Cancer·J H PopeW Scott
Sep 1, 1994·Immunology Today·T F TedderP Engel

❮ Previous
Next ❯

Citations

Aug 29, 1997·The Journal of Experimental Medicine·N SuganoN R Cooper
Jan 7, 1998·Immunological Reviews·C SpethM P Dierich
Feb 26, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Pia Møller Martensen, Just Justesen
Jun 5, 2001·The Journal of Biological Chemistry·S De FalcoG Fassina
Apr 12, 2006·Proceedings of the National Academy of Sciences of the United States of America·C D Shannon-LoweH-J Delecluse
Apr 29, 2004·Journal of Virology·Corina M BorzaLindsey M Hutt-Fletcher
Nov 28, 2007·Annual Review of Pathology·J L Kutok, F Wang
Apr 27, 2007·Journal of Virology·Lindsey M Hutt-Fletcher
May 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Simon JochumReinhard Zeidler
Mar 9, 2000·Journal of Virology·P R SmithP J Farrell
Apr 8, 2009·Pathology Oncology Research : POR·A Saleh YounesGyörgy Berencsi
Mar 1, 1996·Journal of Virology·T J EvansS Swaminathan

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.