Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors

Trends in Microbiology
Laurie PinaudArmelle Phalipon

Abstract

Microbial pathogens possess a diversity of weapons that disrupt host homeostasis and immune defenses, thus resulting in the establishment of infection. The best-characterized system mediating bacterial protein delivery into target eukaryotic cells is the type III secretion system (T3SS) expressed by Gram-negative bacteria, including the human enteric pathogens Shigella, Salmonella, Yersinia, and enteropathogenic/enterohemorragic Escherichia coli (EPEC/EHEC). The emerging global view is that these T3SS-bearing pathogens share similarities in their ability to target key cellular pathways such as the cell cytoskeleton, trafficking, cell death/survival, and the NF-κB and MAPK signaling pathways. In particular, multiple host proteins are targeted in a given pathway, and different T3SS effectors from various pathogens share functional similarities.

Citations

Aug 24, 2018·Cellular Microbiology·Stefanie NorkowskiChristian Rüter
Jul 25, 2018·Infection and Immunity·Rachana Pattani RamachandranBenjamin Aroeti
Apr 10, 2019·Human Vaccines & Immunotherapeutics·Katja BrunnerArmelle Phalipon
May 28, 2019·Emerging Microbes & Infections·Ruixue ZhouDapeng Yan
Sep 2, 2020·Journal of Applied Microbiology·H PanwarA K Puniya
May 16, 2020·Frontiers in Cellular and Infection Microbiology·Xing PanShan Li
Dec 10, 2020·Microorganisms·Waad BajunaidFrançois-Xavier Campbell-Valois
Jan 6, 2021·Nature Communications·Cheng-Rung HuangChang-Shi Chen
Apr 6, 2021·Frontiers in Cellular and Infection Microbiology·Sidi YangYuanyuan Li
May 8, 2021·Cellular Microbiology·Ipsita NandiBenjamin Aroeti
Apr 4, 2019·EcoSal Plus·Maria Lara-Tejero, Jorge E Galán
Aug 11, 2021·Biochemical Society Transactions·Lok ManStuart J Cordwell
Aug 16, 2021·Cellular Microbiology·Flávia VianaGunnar N Schroeder
Oct 16, 2021·Journal of Molecular Biology·Yinan WeiZhenyu Li

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