Aug 21, 2012

Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome

The Journal of Infectious Diseases
Yulan SunDexin Li

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease in China, caused by SFTS virus (SFTSV). Severe SFTS patients can quickly proceed to multiorgan dysfunction and death; however, underlying pathogenic mechanisms remain unclear. Serum samples from 15 fatal and 44 nonfatal SFTS cases were subjected to multiplex-microbead immunoassays to detect a broad spectrum of cytokines. The viral load and virus-specific IgG titers were also tested by real-time PCR and ELISA, respectively. Cytokines IL-1RA, IL-6, IL-10, G-CSF, IP-10, and MCP-1 were elevated in SFTS patients and produced at robust levels in fatal cases. In contrast, cytokines PDGF-BB and RANTES decreased in SFTS patients. These cytokines reverted to normal ranges during the convalescent phase of SFTSV infection. Cytokines IL-1β, IL-8, MIP-1α, and MIP-1β showed a unique pattern of elevation in fatal cases but not in nonfatal cases. However, these cytokines increased in the convalescent phase of nonfatal SFTS cases. Our regression analysis revealed that the serum viral load correlated with these cytokines. Moreover, levels of these cytokines correlated with various clinical parameters and virus-specific IgG titers. The study demonstrates that SFTSV inf...Continue Reading

  • References26
  • Citations92

References

Mentioned in this Paper

Filgrastim
Real-Time Polymerase Chain Reaction
Thrombocytopenia
Antibodies, Viral
Virus Diseases
Granulocyte Colony-Stimulating Factor
Pathogenic Organism
Recombinant Interleukin-10
Interleukin-1
Virus Titer

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