PMID: 666383Jul 1, 1978

Host defense against opportunist microorganisms following trauma. I. Studies to determine the association between changes in humoral components of host defense and septicemia in burned patients

Annals of Surgery
A B BjornsonM L Iserson


Total hemolytic complement (CH(50)), conversion of C3 by inulin, and immunochemical levels of Clq, C4, C2, C3, C5, factor B, C3b inactivator (KAF), and properdin were measured in the sera of 15 patients with severe thermal injury during nine weeks postburn. Five of the 15 patients had multiple episodes of septicemia as documented by positive blood cultures and clinical findings. Decrease in CH(50), Clq, C4, C2, C3, and C5 occurred prior to and during septic episodes in these patients. Although conversion of C3 by inulin was often reduced during septic episodes, levels of factor B and KAF were generally normal or elevated. In only one patient did consumption of complement occurring during septicemia decrease the opsonic capacity of the patient's sera for the patient's infecting microorganism, an isolate of E. coli; sera from the same patient opsonized her infecting strain of S. aureus normally. The microorganisms isolated from the other septic patients, which were opsonized normally by the patients' sera despite complement consumption, were also with one exception strains of Staphylococci. In the nonseptic burned patients, decrease in properdin and C3 conversion by inulin, and increase in C3, factor B and KAF were demonstrated a...Continue Reading


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Feb 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R G MedicusH J Müller-Eberhard
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Jul 1, 1977·Annals of Surgery·A B BjornsonH S Bjornson
Jan 1, 1975·Annual Review of Biochemistry·H J Müller-Eberhard
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Jan 4, 1973·The New England Journal of Medicine·W R McCabe
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Related Concepts

Bacterial Infections
Burn Injury
Hemolytic Complement
Complement C3 precursor
Complement 3b Inactivators

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