PMID: 666383Jul 1, 1978

Host defense against opportunist microorganisms following trauma. I. Studies to determine the association between changes in humoral components of host defense and septicemia in burned patients

Annals of Surgery
A B BjornsonM L Iserson

Abstract

Total hemolytic complement (CH(50)), conversion of C3 by inulin, and immunochemical levels of Clq, C4, C2, C3, C5, factor B, C3b inactivator (KAF), and properdin were measured in the sera of 15 patients with severe thermal injury during nine weeks postburn. Five of the 15 patients had multiple episodes of septicemia as documented by positive blood cultures and clinical findings. Decrease in CH(50), Clq, C4, C2, C3, and C5 occurred prior to and during septic episodes in these patients. Although conversion of C3 by inulin was often reduced during septic episodes, levels of factor B and KAF were generally normal or elevated. In only one patient did consumption of complement occurring during septicemia decrease the opsonic capacity of the patient's sera for the patient's infecting microorganism, an isolate of E. coli; sera from the same patient opsonized her infecting strain of S. aureus normally. The microorganisms isolated from the other septic patients, which were opsonized normally by the patients' sera despite complement consumption, were also with one exception strains of Staphylococci. In the nonseptic burned patients, decrease in properdin and C3 conversion by inulin, and increase in C3, factor B and KAF were demonstrated a...Continue Reading

References

May 1, 1975·The New England Journal of Medicine·D T FearonW R McCabe
Feb 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R G MedicusH J Müller-Eberhard
Nov 1, 1976·The Journal of Trauma·A B BjornsonH S Bjornson
Jul 1, 1977·Annals of Surgery·A B BjornsonH S Bjornson
Jan 1, 1975·Annual Review of Biochemistry·H J Müller-Eberhard
May 10, 1969·Lancet·D CuthbertsonJ A Green
Feb 1, 1970·Archives of Disease in Childhood·M J Schumacher
Jan 4, 1973·The New England Journal of Medicine·W R McCabe
Jan 1, 1973·The Journal of Immunology : Official Journal of the American Association of Immunologists·L G HunsickerK F Austen
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Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Dec 1, 1970·The Journal of Clinical Investigation·R P Messner, J Jelinek
Oct 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·H N CARLISLE, S SASLAW
Jan 1, 1963·Annals of Surgery·H H BALCH

Citations

Jul 1, 1983·World Journal of Surgery·A O Aina
Jan 1, 1980·Intensive Care Medicine·C GeorgeM Rapin
Apr 1, 1981·Intensive Care Medicine·N Clumeck, C George
Feb 8, 2003·Mycoses·M Niewerth, H C Korting
Dec 1, 1982·The Journal of Clinical Investigation·J A GelfandJ F Burke
Jan 11, 2013·Current Opinion in Anaesthesiology·Rachael P Jackman
Jul 1, 1986·The Proceedings of the Nutrition Society·M J McMahon
Apr 1, 1988·World Journal of Surgery·M M KapurM Gidh
Jul 13, 2002·The Surgical Clinics of North America·Daniel L Mollitt
Mar 29, 2012·Transfusion·Rachael P JackmanPhilip J Norris

Related Concepts

Bacterial Infections
Burn Injury
Hemolytic Complement
Complement C3 precursor
Complement 3b Inactivators
Opsonin
Properdin
Pyemia

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