Host defense against the pneumococcus in T-lymphocyte-deficient, nude mice

Nov 1, 1975

Host defense against the pneumococcus in T-lymphocyte-deficient, nude mice

Infection and Immunity

J A Winkelstein, A J Swift

Abstract

Resistance to pneumococcal infection was tested in T-lymphocyte-deficient, nude (nu/nu) mice. Pneumococcal serum opsonizing activity, in vivo phagocytosis of the pneumococcus, and the mean lethal dose for the pneumococcus were all found to be the same in nude mice as in control (+/+) mice. T-lymphocytes do not appear to play a significant role in the host's defense against the pneumococcus.

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Mentioned in this Paper

T-Lymphocyte

Opsonin

Mice, Nude

Lethal Dose 50

Pneumococcal Infections

Phagocytosis

Leukemia, T-Cell

Streptococcus pneumoniae

Cellular Immune Response

About this Paper

PMID: 334

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Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Host defense against the pneumococcus in T-lymphocyte-deficient, nude mice

Abstract

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About this Paper

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Bacterial Pneumonia (ASM)

Bacterial Pneumonia

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