PMID: 334Nov 1, 1975

Host defense against the pneumococcus in T-lymphocyte-deficient, nude mice

Infection and Immunity
J A Winkelstein, A J Swift

Abstract

Resistance to pneumococcal infection was tested in T-lymphocyte-deficient, nude (nu/nu) mice. Pneumococcal serum opsonizing activity, in vivo phagocytosis of the pneumococcus, and the mean lethal dose for the pneumococcus were all found to be the same in nude mice as in control (+/+) mice. T-lymphocytes do not appear to play a significant role in the host's defense against the pneumococcus.

Citations

May 1, 1977·CRC Critical Reviews in Toxicology·J G Vos
Feb 1, 1982·Environmental Health Perspectives·S G Bradley, P S Morahan
Oct 30, 2008·Journal of Immunotoxicology·J G Vos

Related Concepts

Cellular Immune Response
Lethal Dose 50
Mice, Nude
Opsonin
Phagocytosis
Pneumococcal Infections
Streptococcus pneumoniae
T-Lymphocyte

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