Nov 1, 1975

Host defense against the pneumococcus in T-lymphocyte-deficient, nude mice

Infection and Immunity
J A Winkelstein, A J Swift

Abstract

Resistance to pneumococcal infection was tested in T-lymphocyte-deficient, nude (nu/nu) mice. Pneumococcal serum opsonizing activity, in vivo phagocytosis of the pneumococcus, and the mean lethal dose for the pneumococcus were all found to be the same in nude mice as in control (+/+) mice. T-lymphocytes do not appear to play a significant role in the host's defense against the pneumococcus.

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Mentioned in this Paper

T-Lymphocyte
Opsonin
Mice, Nude
Lethal Dose 50
Pneumococcal Infections
Phagocytosis
Leukemia, T-Cell
Streptococcus pneumoniae
Cellular Immune Response

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