Host defense genes in asthma and sepsis and the role of the environment

Current Opinion in Allergy and Clinical Immunology
Li GaoKathleen C Barnes

Abstract

There is growing evidence that innate immunity genes contribute to asthma pathogenesis. At the core of the innate immune response are ubiquitous, soluble fragments of bacterial lipopolysaccharide or endotoxin, and chronic exposure to domestic endotoxin has been shown to influence asthma severity. Asthmatic and atopic individuals are more sensitive to endotoxin than nonallergic individuals, suggesting a role for genetics in the innate immunity response, and the potential for gene-environment interactions. Variants in genes associated with classic innate immunity-related disorders, such as sepsis, may be unique candidates for asthma susceptibility. Candidate genes for asthma and allergic diseases co-associated with sepsis including innate immunity receptors and related molecules (CD14, TLR4 and AOAH) and novel genes such as MYLK provide good examples of pleitropic effects of innate immunity genes, where variants conferring risk to specific traits (i.e. sepsis) under one set of genetic and environmental circumstances confer a reduced risk in a different (but possibly related) clinical outcome (i.e. allergic asthma), and support the 'common variant/multiple disease' hypothesis. Collectively, these observations suggest a greater rol...Continue Reading

References

Mar 24, 1988·The New England Journal of Medicine·T I SørensenT W Teasdale
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C L Hall, Robert S Munford
Nov 17, 1994·Nature·A P Somlyo, A V Somlyo
Mar 1, 1996·The Journal of Infectious Diseases·R LandmannW Zimmerli
Sep 19, 1996·Nature·S E DanielsW O Cookson
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·H L Sweeney
Feb 5, 1999·European Journal of Immunology·J E Rey NoresM O Labéta
Feb 17, 1999·The Journal of Experimental Medicine·S T QureshiD Malo
Oct 12, 1999·Clinical Genetics·P S GaoJ M Hopkin
Mar 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M A AriasM O Labéta
Jun 3, 2000·Nature Genetics·N C ArbourDavid A Schwartz
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·A O MagnanD Vervloet
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·M H DizierF Demenais
Jan 10, 2001·The Journal of Allergy and Clinical Immunology·N AlexisD B Peden
Mar 10, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·M H BrutscheA Woodcock
May 15, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·I PetracheJ G Garcia
Sep 25, 2001·Journal of Applied Physiology·S M Dudek, J G Garcia
Nov 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T D LeVanD Vercelli
Nov 9, 2001·Annual Review of Genetics·T F Mackay
Dec 13, 2001·American Journal of Human Genetics·Timothy D HowardEugene R Bleecker
Feb 14, 2002·The Journal of Allergy and Clinical Immunology·Martin H BrutscheAshley Woodcock
May 9, 2002·Archives of Internal Medicine·Eva LorenzDavid A Schwartz
Jul 19, 2002·The New England Journal of Medicine·Stefan KiechlDavid A Schwartz
Sep 18, 2002·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·R SchifferG Zwadlo-Klarwasser
Nov 20, 2002·Infection and Immunity·Vishwas D JoshiAlan S Cross
Jan 10, 2003·The New England Journal of Medicine·Richard S Hotchkiss, Irene E Karl
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Elsie M AllenAlan R Shuldiner
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
Jun 18, 2003·The Journal of Experimental Medicine·Mingfang LuRobert S Munford
Aug 5, 2003·The Journal of Allergy and Clinical Immunology·Monika WernerJoachim Heinrich
Aug 5, 2003·The Journal of Allergy and Clinical Immunology·Jessica G WooGurjit K Khurana Hershey
Aug 13, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ting Fan LeungChristopher W K Lam
Sep 16, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tatsuya OkamotoAlbert van der Vliet
Dec 12, 2003·BMC Bioinformatics·Kevin G BeckerJim Engel
Jan 22, 2004·Genes and Immunity·I A YangJohn W Holloway
Mar 6, 2004·The Journal of Pediatrics·Jonathan GrischkanSusan Redline
Mar 10, 2004·The Journal of Allergy and Clinical Immunology·Waltraud EderALEX Study Team
Mar 17, 2004·American Journal of Respiratory and Critical Care Medicine·John W HollingsworthDavid A Schwartz
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong JiangMitchell S Cairo
May 22, 2004·Critical Care : the Official Journal of the Critical Care Forum·Jesús VillarCarlos Flores
Jun 18, 2004·American Journal of Respiratory and Critical Care Medicine·Ross LazarusScott T Weiss
Sep 10, 2004·The Journal of Allergy and Clinical Immunology·Malin Fagerås BöttcherOuti Vaarala
Nov 24, 2004·Infection and Immunity·Samithamby JeyaseelanG Scott Worthen
Dec 8, 2004·American Journal of Respiratory and Critical Care Medicine·Shui Q YeJoe G N Garcia
May 10, 2005·American Journal of Respiratory and Critical Care Medicine·Shweta ChoudhryEsteban González Burchard
May 24, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shwu Fan MaJoe G N Garcia
Jun 2, 2005·Cytokine·Chantal van der GraafMihai G Netea
Jun 9, 2005·The Journal of Allergy and Clinical Immunology·April Zambelli-WeinerKathleen C Barnes
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mrigank SrivastavaUlrich A Maus
Oct 21, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ainsley M Sutherland, James A Russell
Dec 24, 2005·Critical Care Medicine·Greg S MartinMarc Moss
Jan 3, 2006·American Journal of Respiratory and Critical Care Medicine·Andrew C MartinPeter N LeSouëf
Jan 6, 2006·Genes and Immunity·C Ober, S Hoffjan
Jan 10, 2006·American Journal of Respiratory Cell and Molecular Biology·Li GaoJoe G N Garcia
Mar 1, 2006·Current Opinion in Allergy and Clinical Immunology·Ian A YangJohn W Holloway
Mar 7, 2006·Pharmacogenomics·Michael E Burczynski, Andrew J Dorner
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Kathleen C BarnesRasika A Mathias
Dec 26, 2006·The Journal of Allergy and Clinical Immunology·Marc A WilliamsSteve N Georas
Jan 2, 2007·The European Respiratory Journal·F D Martinez
Jan 5, 2007·Proceedings of the American Thoracic Society·Nadia Hansel, Gregory B Diette
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoon-Keun KimZhou Zhu

Citations

May 18, 2010·Journal of Lipid Research·Patricia A ThompsonRichard L Kitchens
Jul 16, 2008·The Journal of Allergy and Clinical Immunology·Donata Vercelli
Dec 17, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Rodney R Dietert, Judith T Zelikoff
Jan 30, 2010·The Journal of Allergy and Clinical Immunology·Dmitry N GrigoryevDonald Y M Leung
Apr 25, 2019·Antioxidants & Redox Signaling·Heather LynnJoe G N Garcia
Apr 24, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jonathan M CiencewickiSteven R Kleeberger

Related Concepts

TLR4 protein, human
Asthma
Impacts, Environmental
Resistance, Natural
Lipopolysaccharides
Myosin Light Chain Kinase
Pyemia
CD14 Antigen
MRNA Differential Display
Toll-like receptor 4

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