PMID: 11900322Mar 20, 2002Paper

Host-defense mechanism of the ocular surfaces

Bioscience Reports
R A SackC Morris

Abstract

The defense of the ocular surfaces presents an unique challenge in that not only must integrity be maintained against microbial, inflammatory and physical assault, but it must be done while minimizing the risk of loss of corneal transparency. This puts severe limitations on the degree to which scarring or neovascularization can occur in the cornea secondary to any infectious, inflammatory, immunological or wound healing process. Moreover, this defense system must be equally effective under two extremes of conditions: those found in the open eye and the closed eye environments. It is our contention that these constraints have resulted in the evolution of a highly complex fail-safe defense system that utilizes distinctly different strategies in open and closed eye conditions. The extraordinary effectiveness of this system is evidenced by the fact that despite continued exposure to a microbe rich environment, the external ocular surfaces maintain a very low microbial titer and are highly resistant to breaching by all but a few pathogens. It is the intent of this review to provide a working model of this defense system as it operates under both open and closed eye conditions, to provide evidence in support of this model as well as ...Continue Reading

Citations

Sep 14, 2007·Current Eye Research·Ling C HuangAlison M McDermott
Mar 3, 2010·Anaesthesia and Intensive Care·E K MelaS P Gartaganis
Oct 28, 2011·Current Eye Research·Ruby K PrakasamOliver Stachs
May 5, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·David B AlexanderHiroyuki Tsuda
Mar 23, 2017·Ocular Immunology and Inflammation·Cameron Postnikoff, Maud Gorbet
Aug 23, 2019·Polymers·Courtney LynchViness Pillay
Mar 1, 2005·Journal of Anatomy·Erich Knop, Nadja Knop
Jun 16, 2005·Biopolymers·Yasushi NagaseKenji Kamiyama
Jan 13, 2018·Journal of Virology·Hannah M CreagerJessica A Belser
Dec 4, 2010·The Journal of Biological Chemistry·Atsuko HayashidaPyong Woo Park
Aug 5, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Maureen BoostZhaoran Wang
May 10, 2008·Glycoconjugate Journal·Louise RoyleStephen D Carrington
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Mar 22, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Garima ThakurRoger M Leblanc
May 14, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Garima Thakur, Roger M Leblanc
Nov 30, 2020·Experimental Eye Research·Bethany MillsN Venkatesh Prajna
Jun 8, 2021·Experimental Eye Research·Lawson Ung, James Chodosh
Apr 21, 2010·Biochimie·Jinmei Wang, Miriam Kolko
Jan 12, 2007·The Ocular Surface·Alison M McDermott

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