Host-defense peptides of the skin with therapeutic potential: From hagfish to human

Peptides
J Michael Conlon

Abstract

It is now well established that peptides that were first identified on the basis of their ability to inhibit growth of bacteria and fungi are multifunctional and so are more informatively described as host-defense peptides. In some cases, their role in protecting the organism against pathogenic microorganisms, although of importance, may be secondary. A previous article in the journal (Peptides 2014; 57:67-77) assessed the potential of peptides present in the skin secretions of frogs for development into anticancer, antiviral, immunomodulatory and antidiabetic drugs. This review aims to extend the scope of this earlier article by focusing upon therapeutic applications of host-defense peptides present in skin secretions and/or skin extracts of species belonging to other vertebrate classes (Agnatha, Elasmobranchii, Teleostei, Reptilia, and Mammalia as represented by the human) that supplement their potential role as anti-infectives for use against multidrug-resistant microorganisms.

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Citations

Nov 26, 2015·Nucleic Acids Research·Guangshun WangZhe Wang
Jan 8, 2016·Experimental Dermatology·Maria Luisa MangoniMichael Zasloff
Mar 10, 2016·Journal of Biomolecular Structure & Dynamics·Haitham A YacoubVladimir N Uversky
Jul 13, 2016·Cellular Microbiology·Amalia PortaBruno Maresca
Apr 13, 2018·Frontiers in Pharmacology·Anja PfalzgraffGünther Weindl
Jan 12, 2017·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Élida Cleyse Gomes da MataElisabeth Ferroni Schwartz
Dec 22, 2020·Mass Spectrometry Reviews·Albert T LebedevTatiana Y Samgina
Nov 29, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Raj Kumar ThapaHanne Hjorth Tønnesen
Feb 3, 2021·Rapid Communications in Mass Spectrometry : RCM·Tatiana Y SamginaAlbert T Lebedev
Sep 1, 2021·Peptides·Ernesto M MartellAnselmo J Otero-González

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