Host defenses in murine malaria: immunological characteristics of a protracted state of immunity to Plasmodium yoelii.

Infection and Immunity
J R Murphy

Abstract

Random-bred ICR mice recovered from infection with avirulent Plasmodium yoelii were challenged at various later times with virulent P. yoelii or with another species of Plasmodium, P. berghei, to characterize the immunological nature of the long-term state of immunity generated in response to the avirulent infection. It was found that recovered mice resisted lethal challenge with virulent P. yoelii through at least 416 days after primary infection. However, the quality of this immunity changed as the time after avirulent infection increased. Mice challenged early after recovery were able to prevent the development of patent parasitemia. Later, these immune animals lost this capacity and after challenge infections progressed to patency at the same rate as did nonimmune controls. However, after the establishment of parasitemia, those animals which had encountered the homologous parasite a long time before controlled, and then eliminated, blood infection and survived. The "early" state of immunity was expressed by animals which may have harbored small numbers of viable avirulent parasites and possessed a protective humoral factor which could passively transfer anti-P. yoelii activity to naive recipients. In contrast, animals with ...Continue Reading

References

Jan 1, 1979·The American Journal of Tropical Medicine and Hygiene·J R Murphy, M J Lefford
Jan 1, 1975·Transactions of the Royal Society of Tropical Medicine and Hygiene·N WedderburnM S Hutt
Aug 1, 1975·Experimental Parasitology·R S Desowitz
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Dec 1, 1967·Experimental Parasitology·B T Wellde, E H Sadun
Apr 1, 1944·The Journal of Experimental Medicine·J Maier, L T Coggeshall

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Citations

Nov 22, 2019·The Journal of Experimental Medicine·E Nicole Arroyo, Marion Pepper
Aug 21, 2019·Journal of Tropical Medicine·Joseph Baruch BalukuPauline Byakika-Kibwika

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