Host defenses in murine malaria: nonspecific resistance to Plasmodium berghei generated in response to Mycobacterium bovis infection or Corynebacterium parvum stimulation.

Infection and Immunity
J R Murphy

Abstract

Infection with Mycobacterium bovis (BCG) or injection of killed Corynebacterium parvum protected some strain B6D2 F1 (C57BL/6xDBA/2) mice but did not protect strain ICR or A mice from lethal challenge with Plasmodium berghei strain NYU-2. B6D2 mice were not protected against challenges delivered immediately after intravenous injection of these materials, but rather protection developed by day 7 and persisted through at least day 84. Infections in protected mice progressed to about 10% parasitemia in parallel with infections initiated with the same inoculum in untreated controls. However, infections in most of the protected mice were cleared subsequently, whereas infections in untreated controls were uniformly fatal. A small number of treated mice developed protracted high-level erythrocytic infections, which led to markedly delayed death. BCG-infected mice which survived P. berghei infections had a factor in their sera which protected passively immunized recipients from P. berghei. BCG-infected mice passively immunized with protective serum controlled P. berghei infections better than normal mice given the same amount of the same serum and challenged with the same P. berghei inoculum. The capacity of BCG-infected B6D2 mice to r...Continue Reading

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Citations

Nov 1, 1985·Revista Do Instituto De Medicina Tropical De São Paulo·J J FerraroniC A Speer
Jan 1, 1986·Revista Do Instituto De Medicina Tropical De São Paulo·J J FerraroniC A Speer
Feb 16, 2007·Tropical Medicine & International Health : TM & IH·Amabelia RodriguesBrian Greenwood
Feb 23, 2019·Nature Communications·Jona WalkRobert W Sauerwein
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Mar 1, 1986·Infection and Immunity·K M Brown, J P Kreier
Jun 17, 2020·Cell Host & Microbe·Branko CirovicAndreas Schlitzer

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