Host-directed therapies for parasitic diseases

Future Medicinal Chemistry
Bhawana SinghAbhay R Satoskar

Abstract

Parasitic infections are responsible for significant morbidity and mortality throughout the world. Management strategies rely primarily on antiparasitic drugs that have side effects and risk of drug resistance. Therefore, novel strategies are needed for treatment of parasitic infections. Host-directed therapy (HDT) is a viable alternative, which targets host pathways responsible for parasite invasion/survival/pathogenicity. Recent innovative combinations of genomics, proteomics and computational biology approaches have led to discovery of several host pathways that could be promising targets for HDT for treating parasitic infections. Herein, we review major advances in HDT for parasitic disease with regard to core regulatory pathways and their interactions.

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Citations

May 5, 2020·Frontiers in Cellular and Infection Microbiology·Nathan RyanSteve Oghumu
Dec 22, 2020·International Journal for Parasitology·Nicholas C SmithGiel G van Dooren
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May 26, 2020·Pharmaceutical Nanotechnology·Rodrigo Sanabria

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Methods Mentioned

BETA
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