PMID: 6401796Feb 1, 1983Paper

Host discrimination of Mycoplasma pneumoniae proteinaceous immunogens

The Journal of Experimental Medicine
D K LeithJ B Baseman

Abstract

The immune response of experimentally infected hamsters and human patients to Mycoplasma pneumoniae was examined by radioimmunoprecipation in conjunction with gel electrophoresis and fluorography. Both intrinsically and extrinsically labeled mycoplasma proteins were coincubated with acute and convalescent sera in a radioimmunoprecipitation assay. Two M. pneumoniae proteins were selectively precipitated by convalescent sera. These predominant immunogens were trypsin-sensitive, antibody-accessible surface proteins that co-migrate on polyacrylamide gels with proteins P1 and P2, which were previously implicated by us as mediators of cytadsorption. Anti-M. pneumoniae antiserum did not precipitate radiolabeled antigens derived from Mycoplasma orale or Mycoplasma salivarium. These data indicate that M. pneumoniae infection stimulates a specific and highly targeted host antibody response to key proteinaceous immunogens.

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Citations

Jan 1, 1990·Journal of Clinical Pharmacology·L G MillerR C Bowman
Nov 11, 1983·Journal of Immunological Methods·J Morrison-PlummerJ B Baseman
Oct 1, 1985·Veterinary Immunology and Immunopathology·C J Howard, G Taylor
Dec 1, 1987·Microbial Pathogenesis·V V Tryon, J B Baseman
Jan 1, 1984·Annales de microbiologie·I KahaneA Reisch-Saada
Feb 1, 1988·The Journal of Experimental Medicine·S F DalloJ B Baseman
Oct 1, 2011·The Journal of Infectious Diseases·T R KannanJoel B Baseman
Jun 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L HirschbergA Krook
Feb 12, 2013·Journal of Bacteriology·Clinton A Page, Duncan C Krause
Jun 1, 1991·Microbial Pathogenesis·S F Dallo, J B Baseman
May 8, 2010·Journal of Medical Microbiology·María A MartínezLuis F Avendaño
Jan 4, 2012·FEMS Microbiology Reviews·Cornelis VinkH Steven Seifert
Oct 16, 2020·Nature Communications·David VizarragaDavid Aparicio
Jan 1, 1991·Infection and Immunity·A B SaadaI Kahane
Dec 1, 1987·Infection and Immunity·C J SuJ B Baseman
Jul 1, 1990·Journal of Clinical Microbiology·C J SuJ B Baseman
Nov 1, 1988·Journal of Clinical Microbiology·J B BasemanD L Rose
Aug 1, 1986·Infection and Immunity·J Morrison-PlummerJ B Baseman
Dec 1, 1994·Journal of Bacteriology·L B DirksenD C Krause
Jan 1, 1985·Infection and Immunity·E PearlmanB I Eisenstein
Jun 1, 1986·Journal of Clinical Microbiology·G H PalmerT C McGuire
Aug 1, 1990·Infection and Immunity·C J SuJ B Baseman

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