Abstract
Pathologic infections are accompanied by a collection of short-term behavioral perturbations collectively termed sickness behaviors [1, 2]. These include changes in body temperature, reduced eating and drinking, and lethargy and mimic behaviors of animals in torpor and hibernation [1, 3-6]. Sickness behaviors are important, pathogen-specific components of the host response to infection [1, 3, 7-9]. In particular, host anorexia has been shown to be beneficial or detrimental depending on the infection [7, 8]. While these studies have illuminated the effects of anorexia on infection, they consider this behavior in isolation from other behaviors and from its effects on host metabolism and energy. Here, we explored the temporal dynamics of multiple sickness behaviors and their effect on host energy and metabolism throughout infection. We used the Plasmodium chabaudi AJ murine model of malaria as it causes severe pathology from which most animals recover. We found that infected animals did become anorexic, skewing their metabolism toward fatty acid oxidation and ketosis. Metabolism of fats requires oxygen for the production of ATP. In this model, animals also suffer severe anemia, limiting their ability to carry oxygen concurrent wit...Continue Reading
References
Jun 1, 1992·Journal of Applied Physiology·A L CooperN J Rothwell
Jan 1, 1989·Life Sciences·A L CooperN J Rothwell
Mar 28, 1987·Lancet·N J WhiteJ Brown
Sep 19, 1987·British Medical Journal·W OkitolondaJ C Henquin
Sep 1, 1994·Infection and Immunity·G S Yap, M M Stevenson
Jul 1, 1993·Critical Care Medicine·G KreymannH Greten
Mar 1, 1996·Infectious Disease Clinics of North America·M J KlugerD Soszynski
May 30, 1998·QJM : Monthly Journal of the Association of Physicians·M EnglishK Marsh
Aug 31, 1999·Parasitology·G N JakemanW E Collins
Jun 6, 2003·QJM : Monthly Journal of the Association of Physicians·K MaitlandC R J C Newton
Jan 1, 1955·The Journal of Experimental Medicine·R J DUBOS
Nov 5, 2003·Nature Genetics·Gundula Min-OoPhilippe Gros
Feb 24, 2004·Annual Review of Physiology·Fritz Geiser
May 1, 2007·Blood Cells, Molecules & Diseases·Gundula Min-OoPhilippe Gros
Apr 22, 2008·Animal Health Research Reviews·Ian Tizard
May 8, 2008·Haematologica·Pierre M Durand, Theresa L Coetzer
Jul 15, 2009·PLoS Biology·Janelle S Ayres, David S Schneider
Apr 2, 2011·Nature Protocols·Philip J SpenceJoanne Thompson
Aug 13, 2011·Genes and Immunity·J BerghoutP Gros
Nov 24, 2011·International Journal of Biological Sciences·Douglas J PerkinsJohn Michael Ong'echa
Jan 10, 2012·Annual Review of Immunology·Janelle S Ayres, David S Schneider
Mar 1, 2012·Science·Ruslan MedzhitovMiguel P Soares
Mar 12, 2013·Current Biology : CB·Fritz Geiser
Mar 19, 2013·Frontiers in Physiology·John R Speakman
Oct 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Vincent van der VinneRoelof A Hut
Apr 19, 2016·PLoS Biology·Brenda Y TorresDavid S Schneider
Sep 10, 2016·Cell·Andrew WangRuslan Medzhitov
Nov 7, 2016·Pathogens and Disease·Alexandria M Palaferri Schieber, Janelle S Ayres
Jan 28, 2017·Cell·Sheila RaoJanelle S Ayres
Apr 21, 2017·PloS One·Sanchit GuptaJohanna P Daily
Sep 28, 2017·Nature Microbiology·Vanessa Zuzarte-LuísMaria M Mota
Citations
Jan 24, 2019·Annual Review of Immunology·Rui MartinsMiguel P Soares
Jun 13, 2019·Integrative and Comparative Biology·Jessica L Hite, Clayton E Cressler
Jul 7, 2020·British Journal of Pharmacology·Gabriella AvielloGiuseppe D'Agostino
Oct 31, 2018·Nature Communications·Leen VandermostenPhilippe E Van den Steen
Jul 31, 2019·Scientific Reports·Kimberley F PriorSarah E Reece
Sep 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Lara Labarta-BajoElina I Zúñiga
Mar 6, 2019·Proceedings of the National Academy of Sciences of the United States of America·Susana RamosMiguel P Soares
Oct 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Andrew WangRuslan Medzhitov
Jan 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Andrew WangRuslan Medzhitov
Aug 17, 2020·PLoS Pathogens·Danielle A S RodriguesMarcelo T Bozza
Oct 7, 2020·ELife·Michelle M LissnerDavid Schneider
Dec 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kevin ManAjay Chawla
Jan 8, 2021·PLoS Pathogens·Hendrik PossemiersPhilippe E Van den Steen
Oct 14, 2019·Trends in Parasitology·Leen VandermostenPhilippe E Van den Steen
Mar 24, 2021·ELife·Wiebke NahrendorfPhilip J Spence
Feb 16, 2021·Journal of Evolutionary Biology·Katherine E Roberts, Ben Longdon
Jun 29, 2021·Frontiers in Immunology·Riguo LanYulong Yin
Sep 23, 2021·Proceedings. Biological Sciences·Agnes PiecykMartin Kalbe
Oct 6, 2021·MBio·Nicole M DavisDavid S Schneider
Oct 5, 2021·Frontiers in Cellular and Infection Microbiology·Andrew J JezewskiAudrey R Odom John