Host Energy Source Is Important for Disease Tolerance to Malaria

Current Biology : CB
Katherine CumnockDavid S Schneider

Abstract

Pathologic infections are accompanied by a collection of short-term behavioral perturbations collectively termed sickness behaviors [1, 2]. These include changes in body temperature, reduced eating and drinking, and lethargy and mimic behaviors of animals in torpor and hibernation [1, 3-6]. Sickness behaviors are important, pathogen-specific components of the host response to infection [1, 3, 7-9]. In particular, host anorexia has been shown to be beneficial or detrimental depending on the infection [7, 8]. While these studies have illuminated the effects of anorexia on infection, they consider this behavior in isolation from other behaviors and from its effects on host metabolism and energy. Here, we explored the temporal dynamics of multiple sickness behaviors and their effect on host energy and metabolism throughout infection. We used the Plasmodium chabaudi AJ murine model of malaria as it causes severe pathology from which most animals recover. We found that infected animals did become anorexic, skewing their metabolism toward fatty acid oxidation and ketosis. Metabolism of fats requires oxygen for the production of ATP. In this model, animals also suffer severe anemia, limiting their ability to carry oxygen concurrent wit...Continue Reading

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Citations

Jan 24, 2019·Annual Review of Immunology·Rui MartinsMiguel P Soares
Jun 13, 2019·Integrative and Comparative Biology·Jessica L Hite, Clayton E Cressler
Jul 7, 2020·British Journal of Pharmacology·Gabriella AvielloGiuseppe D'Agostino
Oct 31, 2018·Nature Communications·Leen VandermostenPhilippe E Van den Steen
Sep 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Lara Labarta-BajoElina I Zúñiga
Mar 6, 2019·Proceedings of the National Academy of Sciences of the United States of America·Susana RamosMiguel P Soares
Oct 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Andrew WangRuslan Medzhitov
Jan 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Andrew WangRuslan Medzhitov
Dec 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kevin ManAjay Chawla
Jan 8, 2021·PLoS Pathogens·Hendrik PossemiersPhilippe E Van den Steen
Oct 14, 2019·Trends in Parasitology·Leen VandermostenPhilippe E Van den Steen
Feb 16, 2021·Journal of Evolutionary Biology·Katherine E Roberts, Ben Longdon
Oct 5, 2021·Frontiers in Cellular and Infection Microbiology·Andrew J JezewskiAudrey R Odom John

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