Host-etiological agent interactions in intranasally and intraperitoneally induced Cryptococcosis in mice.

Infection and Immunity
T S LimL K Cauley

Abstract

Inbred CBA/J mice were used in developing a defined in vivo model for studying host-parasite relationships in cryptococcosis. Mice were infected either intranasally or intraperitoneally with 10(3) viable Cryptococcus neoformans cells. At weekly intervals over a 92-day period, C. neoformans growth profiles in the lungs, spleens, livers, and brains of the infected animals were determined. In addition, humoral and delayed-type hypersensitivity responses and cryptococcal antigen levels were assayed in these mice. Intranasally infected mice developed strong delayed-type hypersensitivity reactions in response to cryptococcal culture filtrate (CneF) antigen, and there was good correlation between acquisition of delayed-type hypersensitivity and the reduction of C. neoformans cell numbers in infected tissues. In contrast, intraperitoneally infected mice displayed greater numbers of C. neoformans cells in tissues and had somewhat suppressed delayed-type hypersensitivity responses to CneF antigen. Anticryptococcal antibodies were not detected in intranasally or intraperitoneally infected mice, but cryptococcal polysaccharide antigen titers were relatively high in both groups. The transfer of sensitized spleen cells from intranasally infe...Continue Reading

References

Sep 1, 1977·Infection and Immunity·J B NeilsonG S Bulmer
May 1, 1978·Infection and Immunity·M A Dykstra, L Friedman
Dec 18, 1978·Mycopathologia·F StaibA Blisse
Dec 1, 1977·Infection and Immunity·M J Lefford
Jun 1, 1975·The Journal of Allergy and Clinical Immunology·S C Schimpff, J E Bennett
Oct 1, 1974·Cellular Immunology·J R Graybill, R H Alford
Sep 1, 1974·Radiology·J GordonsonE N Sargent
Jan 1, 1968·Journal of Bacteriology·G S Bulmer, M D Sans
Sep 1, 1972·The American Journal of Medicine·J L Lewis, S Rabinovich
Oct 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·N BLOOMFIELDD F ELMENDORF
Jun 1, 1964·Journal of Bacteriology·C D SMITHM L FURCOLOW
Apr 1, 1965·The Journal of Pathology and Bacteriology·A K PERCEVAL
Aug 1, 1951·Proceedings of the Society for Experimental Biology and Medicine·J M NEILLD W McCAULEY
Jun 1, 1970·Infection and Immunity·F FarhiJ R Tacker

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Citations

Jun 1, 1983·Infection and Immunity·J E DomerJ W Murphy
Jun 1, 1982·Infection and Immunity·P Y Fung, J W Murphy
Jul 19, 2000·Infection and Immunity·T McGaha, J W Murphy
Sep 1, 1987·Infection and Immunity·C A SalkowskiE Balish
Jun 20, 1983·Mycopathologia·C M RieraR Nobile
Jan 1, 1994·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·Y FukazawaP Puccetti
Jun 17, 2010·Mycopathologia·Mark B KrockenbergerWieland Meyer

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