Host Factors and Pathways Involved in the Entry of Mosquito-Borne Alphaviruses.

Trends in Microbiology
Lien De CaluwéKoen Bartholomeeusen

Abstract

Chikungunya virus (CHIKV) is an arthropod-borne virus that has re-emerged recently and has spread to previously unaffected regions, resulting in millions of infections worldwide. The genus Alphavirus, in the family Togaviridae, contains several members with a similar potential for epidemic emergence. In order for CHIKV to replicate in targeted cell types it is essential for the virus to enter these cells. In this review, we summarize our current understanding of the versatile and promiscuous steps in CHIKV binding and entry into human and mosquito host cells. We describe the different entry pathways, receptors, and attachment factors so far described for CHIKV and other mosquito-borne alphaviruses and discuss them in the context of tissue tropism and potential therapeutic targeting.

References

Aug 8, 1998·Journal of Virology·A P Byrnes, D E Griffin
Jan 1, 1955·Transactions of the Royal Society of Tropical Medicine and Hygiene·W H LUMSDEN
Jul 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Aaron C BraultScott C Weaver
May 17, 2005·Virology·May La LinnAndreas Suhrbier
Feb 25, 2006·Cell·Mark Marsh, Ari Helenius
Jul 3, 2007·PLoS Pathogens·Marion SourisseauOlivier Schwartz
Dec 12, 2007·PLoS Pathogens·Konstantin A TsetsarkinStephen Higgs
Apr 9, 2008·Current Medicinal Chemistry·Y S BoriskinS J Polyak
Sep 8, 2009·Virology·Maxime SolignatChristian Devaux
May 4, 2010·PLoS Neglected Tropical Diseases·Michelle M ThiboutotKaruppiah Muthumani
Jun 17, 2010·Nature Reviews. Microbiology·Olivier Schwartz, Matthew L Albert
Jun 24, 2010·Archives of Virology·Mandar S PaingankarDileep N Deobagkar
Dec 3, 2010·Nature·Long LiMichael G Rossmann
Mar 26, 2010·Viruses·Margaret KielianMaofu Liao
Aug 17, 2011·Cell Host & Microbe·Katie M Stiles, Margaret Kielian
Sep 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Christina L GardnerWilliam B Klimstra
Dec 23, 2011·Journal of Virology·N L ForresterW I Lipkin
Feb 9, 2012·Advances in Virology·Jason Yat-Sing LeungJustin Jang Hann Chu
Mar 6, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Bernard GayLaurence Briant
Aug 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Farooq NasarScott C Weaver
Sep 22, 2012·Journal of Medical Virology·Phitchayapak WintachaiDuncan R Smith
Oct 5, 2012·Journal of Virology·Anthony J Snyder, Suchetana Mukhopadhyay
Feb 15, 2013·PLoS Neglected Tropical Diseases·Regina Ching Hua LeeJustin Jang Hann Chu
Feb 21, 2013·Transactions of the Royal Society of Tropical Medicine and Hygiene·Diawo DialloMawlouth Diallo
May 3, 2013·Journal of Virology·Claudia Sánchez-San MartínMargaret Kielian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.