Host Factors Impact Vaccine Efficacy: Implications for Seasonal and Universal Influenza Vaccine Programs

Journal of Virology
Santosh Dhakal, Sabra L Klein

Abstract

Influenza is a global public health problem. Current seasonal influenza vaccines have highly variable efficacy, and thus attempts to develop broadly protective universal influenza vaccines with durable protection are under way. While much attention is given to the virus-related factors contributing to inconsistent vaccine responses, host-associated factors are often neglected. Growing evidences suggest that host factors including age, biological sex, pregnancy, and immune history play important roles as modifiers of influenza virus vaccine efficacy. We hypothesize that host genetics, the hormonal milieu, and gut microbiota contribute to host-related differences in influenza virus vaccine efficacy. This review highlights the current insights and future perspectives into host-specific factors that impact influenza vaccine-induced immunity and protection. Consideration of the host factors that affect influenza vaccine-induced immunity might improve influenza vaccines by providing empirical evidence for optimizing or even personalizing vaccine type, dose, and use of adjuvants for current seasonal and future universal influenza vaccines.

References

Aug 1, 1979·Journal of Clinical Microbiology·D L MurrayJ W St Geme
Jul 13, 2001·Menopause : the Journal of the North American Menopause Society·K DeguchiT Aono
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria Saurwein-TeisslBeatrix Grubeck-Loebenstein
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Insoo KangJoe Craft
Sep 19, 2008·The New England Journal of Medicine·K ZamanMark C Steinhoff
Dec 10, 2008·Archives of Internal Medicine·Renata J M EnglerUNKNOWN Walter Reed Health Care System Influenza Vaccine Consortium
Jan 14, 2009·The Journal of Experimental Medicine·Siim PauklinSvend K Petersen-Mahrt
Feb 21, 2009·Vaccine·Gregory A PolandRobert M Jacobson
Jul 1, 2009·The New England Journal of Medicine·Shanta M Zimmer, Donald S Burke
Nov 6, 2009·JAMA : the Journal of the American Medical Association·Janice K LouieUNKNOWN California Pandemic (H1N1) Working Group
Jan 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander PandaAlbert C Shaw
Sep 30, 2010·The Journal of Infectious Diseases·Kawsar R TalaatRuth A Karron
Dec 15, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tamara K BerthoudSarah C Gilbert
Jan 7, 2011·Clinical and Vaccine Immunology : CVI·R BodewesG F Rimmelzwaan
Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Takeshi IchinoheAkiko Iwasaki
Jul 12, 2011·Nature Immunology·Helder I NakayaBali Pulendran
Oct 26, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P A SheridanM A Beck
Oct 29, 2011·The Lancet Infectious Diseases·Michael T OsterholmEdward A Belongia
Jan 28, 2012·International Immunology·Daniela FrascaBonnie B Blomberg
Feb 23, 2012·Obstetrics and Gynecology·Rhoda S SperlingThomas M Moran
Feb 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Melissa B PearceTerrence M Tumpey
Jul 26, 2012·PLoS Pathogens·Justin LesslerDerek A T Cummings

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Citations

Apr 24, 2020·Emerging Microbes & Infections·Na LeiYuelong Shu
Jun 3, 2020·Immunological Reviews·Daniela FrascaLaura Haynes
Feb 11, 2020·Human Vaccines & Immunotherapeutics·Giuseppe MaranoSilvana Castaldi
Oct 7, 2020·Annual Review of Cell and Developmental Biology·Daniela FrascaBonnie B Blomberg
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Rebekah HonceStacey Schultz-Cherry
Jan 31, 2021·Rheumatology International·Tsvetelina Velikova, Tsvetoslav Georgiev
Dec 10, 2020·Immunity & Ageing : I & a·Daniela Frasca, Bonnie B Blomberg
Feb 25, 2021·Human Vaccines & Immunotherapeutics·Jennifer E GerberDaniel A Salmon
Mar 2, 2021·Journal of Infection and Public Health·Marwan ElBagouryAmy Hutchinson
Mar 4, 2021·Pharmacological Reviews·Franck Mauvais-JarvisJoshua B Rubin
Jan 31, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Seyed M MoghadasAlison P Galvani
Mar 19, 2021·Frontiers in Microbiology·Kyla L Hooker, Vitaly V Ganusov
Mar 20, 2021·Vaccine·Manish SadaranganiSoren Gantt
Jan 1, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi· Priyanka, Om Prakash Choudhary
Apr 8, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Angélica J M de LeeuwCornelis F Calkhoven
Jun 22, 2021·Human Vaccines & Immunotherapeutics·Jennifer E GerberDaniel A Salmon
Jun 25, 2021·Journal of Midwifery & Women's Health·Nell L Tharpe, Linda McDaniel
Jul 13, 2021·Health Science Reports·Sreeja RoyYoichi Furuya
Nov 9, 2021·PloS One·Aldiane Gomes de Macedo BacurauPriscila Maria Stolses Bergamo Francisco
Apr 30, 2021·Obesity Facts·Dror DickerNathalie J Farpour-Lambert
Dec 1, 2021·Journal of Medical Virology·Shahab Falahi, Azra Kenarkoohi

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