Host gene expression classifiers diagnose acute respiratory illness etiology

Science Translational Medicine
Ephraim L TsalikChristopher W Woods

Abstract

Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in pathogen-based diagnostics, most patients receive inappropriate antibiotics. Host response biomarkers offer an alternative diagnostic approach to direct antimicrobial use. This observational cohort study determined whether host gene expression patterns discriminate noninfectious from infectious illness and bacterial from viral causes of acute respiratory infection in the acute care setting. Peripheral whole blood gene expression from 273 subjects with community-onset acute respiratory infection (ARI) or noninfectious illness, as well as 44 healthy controls, was measured using microarrays. Sparse logistic regression was used to develop classifiers for bacterial ARI (71 probes), viral ARI (33 probes), or a noninfectious cause of illness (26 probes). Overall accuracy was 87% (238 of 273 concordant with clinical adjudication), which was more accurate than procalcitonin (78%, P < 0.03) and three published classifiers of bacterial versus viral infection (78 to 83%). The classifiers developed here externally validated in five publicly available data sets (AUC, 0.90 to 0.99). A sixth pu...Continue Reading

References

Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M I BukrinskyM Stevenson
Dec 17, 2003·Journal of Gastroenterology and Hepatology·Kevin DolanRobert Sutton
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liliana SimonJacques Lacroix
Jun 30, 2009·International Journal of Antimicrobial Agents·Matthew S Dryden
Jul 15, 2009·International Journal of Antimicrobial Agents·I M Gould
Oct 23, 2009·Journal of Clinical Microbiology·Ephraim L TsalikChristopher W Woods
Dec 16, 2009·International Journal of Antimicrobial Agents·Adolf W Karchmer
Apr 8, 2010·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Seth W GlickmanEmanuel P Rivers
Nov 8, 2011·The Journal of Emergency Medicine·Ephraim L TsalikChristopher W Woods
Aug 18, 2012·Critical Care : the Official Journal of the Critical Care Forum·Grant P ParnellBenjamin M Tang
Jul 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Xinran HuGregory A Storch
Jul 26, 2013·Science Translational Medicine·Raymond J LangleyStephen F Kingsmore
Jul 28, 2013·The Journal of Antimicrobial Chemotherapy·Daniel J ShapiroAdam L Hersh
Aug 1, 2013·The Journal of Infectious Diseases·Jethro A HerbergMichael Levin
Sep 21, 2013·Science Translational Medicine·Aimee K ZaasGeoffrey S Ginsburg
May 3, 2014·The New England Journal of Medicine·Suzanne T AndersonBrian Eley
Jun 12, 2014·BMC Medicine·Grace C LeeChristopher R Frei
Dec 30, 2014·Genome Medicine·Ephraim L TsalikStephen F Kingsmore

❮ Previous
Next ❯

Citations

Apr 5, 2016·Expert Review of Anti-infective Therapy·Fiona Mei Shan Teo, Justin Jang Hann Chu
Apr 27, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A DixJ Linde
Dec 29, 2016·Oral Diseases·N Kravchenko-Balasha, D J Aframian
Apr 11, 2017·The Lancet. Respiratory Medicine·Andrew T Pavia
Apr 14, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephen P Bergin, Ephraim L Tsalik
Sep 21, 2017·Vaccines·Emily Speranza, John H Connor
Oct 6, 2017·Nucleic Acids Research·Xiangtian YuLuonan Chen
Apr 28, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Liat Ashkenazi-HoffnungOded Scheuerman
Jun 26, 2018·Expert Review of Molecular Diagnostics·Emily C LydonEphraim L Tsalik
Mar 17, 2018·American Journal of Respiratory and Critical Care Medicine·Charles S Dela CruzJoseph P Mizgerd
Nov 1, 2016·Journal of Clinical Microbiology·Zachary E HolcombMicah T McClain
Oct 20, 2018·The Journal of Infectious Diseases·Jinsheng YuGregory A Storch
Nov 14, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David van DuinMinggui Wang
Jan 10, 2019·Expert Review of Molecular Diagnostics·D M VerboomO L Cremer
Feb 17, 2018·Nature Communications·Timothy E SweeneyRaymond J Langley
Jun 18, 2017·The European Respiratory Journal·Octavio Ramilo, Asuncion Mejias
Aug 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Alexandre Pellan ChengIwijn De Vlaminck
Jul 8, 2016·Science Translational Medicine·Timothy E SweeneyPurvesh Khatri
Feb 8, 2020·Expert Review of Molecular Diagnostics·Peter J DaileyMark Holodniy
Feb 16, 2020·International Journal of Molecular Sciences·Manuela CarugatiIfalt Working Group
Oct 23, 2019·The Journal of Applied Laboratory Medicine·Nour Al JalboutJeremiah S Hinson
Oct 18, 2016·Current Opinion in Ophthalmology·Thuy Doan, Benjamin A Pinsky
Jun 4, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ying LiuScott R Evans
Sep 8, 2017·African Journal of Laboratory Medicine·Iruka N Okeke
May 15, 2018·Journal of Leukocyte Biology·Jillian O GracePatricia C Fulkerson
Jun 28, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Heike KollmusKlaus Schughart
Jan 9, 2019·Frontiers in Microbiology·Gregory D PooreEphraim L Tsalik
Dec 24, 2018·Expert Review of Molecular Diagnostics·Robert DuncanBryan Lanning
Jul 28, 2020·Frontiers in Bioengineering and Biotechnology·Yang LiXuejun Ma
Jul 24, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Xiaoying GuBin Cao
May 2, 2018·Nature Chemistry·Randolph LopezGeorg Seelig
May 26, 2018·Current Opinion in Infectious Diseases·Patricia S FontelaJesse Papenburg
Nov 30, 2018·Proceedings of the National Academy of Sciences of the United States of America·Charles LangelierJoseph L DeRisi
May 3, 2019·Journal of Clinical Microbiology·Ian L GunsolusNathan A Ledeboer
Mar 30, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Henry F Chip ChambersUNKNOWN Antibacterial Resistance Leadership Group (ARLG)

❮ Previous
Next ❯

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