Host genetic factors and mycobacterial infections: lessons from single gene disorders affecting innate and adaptive immunity

Microbes and Infection
Rainer DoffingerDinakantha S Kumararatne

Abstract

This review summarizes the association of increased susceptibility to mycobacterial disease in patients with genetic defects affecting innate and adaptive immunity. The optimum function of CD4 T-cell and macrophage function is critically important for immunity against mycobacteria. Antibody, complement and neutrophil function is not required for effective anti-mycobacterial immunity.

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Apr 29, 2008·American Journal of Respiratory Cell and Molecular Biology·Elizabeth P SampaioSteven M Holland
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Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul J MaglioneJohn Chan

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