Host genetic susceptibility to viral infections: the role of type I interferon induction.

Genes and Immunity
Marie BourdonXavier Montagutelli

Abstract

The innate immune response is the major front line of defense against viral infections. It involves hundreds of genes with antiviral properties which expression is induced by type I interferons (IFNs) and are therefore called interferon stimulated genes (ISGs). Type I IFNs are produced after viral recognition by pathogen recognition receptors, which trigger a cascade of activation events. Human and mouse studies have shown that defective type I IFNs induction may hamper the ability to control viral infections. In humans, moderate to high-effect variants have been identified in individuals with particularly severe complications following viral infection. In mice, functional studies using knock-out alleles have revealed the specific role of most genes of the IFN pathway. Here, we review the role of the molecular partners of the type I IFNs induction pathway and their implication in the control of viral infections and of their complications.

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Citations

Apr 4, 2021·Vaccines·Judith Estévez-HerreraAgustín Valenzuela-Fernández
Apr 4, 2021·International Journal of Molecular Sciences·Fanny PojeroAnna Aiello
Jul 10, 2021·Immunotherapy Advances·Shane M O'Carroll, Luke A J O'Neill
Aug 19, 2021·Immunological Reviews·Nandan S GokhaleRam Savan

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