Host glycan utilization within the Bacteroidetes Sus-like paradigm.

Glycobiology
Haley A Brown, Nicole M Koropatkin

Abstract

The Bacteroidetes are numerically abundant Gram-negative organisms of the distal human gut with a greatly expanded capacity to degrade complex glycans. A subset of these are adept at scavenging host glycans within this environment, including mucin O-linked glycans, N-linked glycoproteins and highly sulfated glycosaminoglycans (GAGs) such as heparin (Hep) and chondroitin sulfate (CS). Several recent biochemical studies have revealed the specific polysaccharide utilization loci (PULs) within the model symbiont Bacteroides thetaiotaomicron for the deconstruction of these host glycans. Here we discuss the Sus-like paradigm that defines glycan uptake by the Bacteroidetes and the salient details of the PULs that target heparin/heparan sulfate (HS) and chondroitin sulfate/dermatan sulfate (DS)/hyaluronic acid (HA), respectively, in B. thetaiotaomicron. The ability of the Bacteroidetes to target highly sulfated host glycans is key to their success in the gut environment but can lead to inflammation in susceptible hosts. Therefore, our continued understanding of the molecular strategies employed by these bacteria to scavenge carbohydrate nutrition is likely to lead to novel ways to alter their metabolism to promote host health.

References

Sep 25, 2004·International Journal of Systematic and Evolutionary Microbiology·Muriel DerrienWillem M de Vos
Mar 26, 2005·Science·Justin L SonnenburgJeffrey I Gordon
Jun 13, 2006·The Journal of Biological Chemistry·Olivier BerteauSylvie Rabot
Feb 9, 2007·The Journal of Biological Chemistry·Louise E TailfordHarry J Gilbert
Dec 19, 2008·Chemical Biology & Drug Design·Neha S Gandhi, Ricardo L Mancera
Jun 26, 2009·The Journal of Biological Chemistry·Eric C MartensJeffrey I Gordon
Oct 6, 2009·The Journal of Biological Chemistry·Young-Hyun HanMiroslaw Cygler
Jan 19, 2010·Nature Chemical Biology·Yanping ZhuGideon J Davies
Jul 22, 2010·The American Journal of Gastroenterology·Chin Wen PngTimothy H J Florin
Mar 9, 2011·The Journal of Clinical Investigation·Jianxin FuLijun Xia
Nov 1, 2011·Cell Host & Microbe·Angela MarcobalJustin L Sonnenburg
Jan 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Andrew J ThompsonGideon J Davies
Apr 12, 2012·Nature Reviews. Microbiology·Nicole M KoropatkinEric C Martens
Apr 26, 2012·Proceedings of the National Academy of Sciences of the United States of America·Elisabeth C LoweDavid N Bolam
May 9, 2012·Handbook of Experimental Pharmacology·Zachary ShriverRam Sasisekharan
Jun 16, 2012·Nature·UNKNOWN Human Microbiome Project Consortium
May 8, 2013·Molecular Microbiology·Theresa E RogersEric C Martens
Jun 12, 2013·Nature Reviews. Microbiology·Abdessamad El KaoutariBernard Henrissat
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Jul 22, 2014·Molecular Microbiology·Varsha RaghavanEduardo A Groisman
Sep 24, 2015·Nature Communications·Hai LiAndrew J Macpherson
Jul 8, 2016·Nature·Justin L Sonnenburg, Fredrik Bäckhed
Jul 10, 2016·Journal of Molecular Biology·Darrell W Cockburn, Nicole M Koropatkin

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Citations

Oct 13, 2020·Glycobiology·Andrew Bell, Nathalie Juge
Jan 16, 2021·Molecular Microbiology·Rebecca M PolletNicole M Koropatkin
Apr 18, 2021·International Journal of Biological Macromolecules·Pedro J Fernandez-JuliaDouwe van Sinderen
Jul 3, 2021·Glycobiology·Christine M Szymanski, Nicole M Koropatkin

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