Host glycans and antigen presentation.

Microbes and Infection
Sean O Ryan, Brian A Cobb

Abstract

The cell-mediated adaptive immune response depends upon the activation of T cells via recognition of antigen in the context of a major histocompatibility complex (MHC) molecule. Although studies have shown that alterations in T cell receptor glycosylation reduces the activation threshold, the data on MHC is far less definitive. Here, we discuss the data on MHC glycosylation and the role the glycans might play during the adaptive host response.

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Citations

Mar 15, 2013·Trends in Immunology·Jenny L JohnsonBrian A Cobb
Nov 16, 2013·Nature Chemical Biology·Margreet A Wolfert, Geert-Jan Boons
Jun 29, 2016·Journal of Proteome Research·Clément P DelannoyYann Guérardel
Mar 19, 2020·Human Vaccines & Immunotherapeutics·Elien De BousserNele Festjens

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