Host-guest interaction mediated polymeric assemblies: multifunctional nanoparticles for drug and gene delivery.

ACS Nano
Jianxiang ZhangPeter X Ma

Abstract

Novel core-shell structured nanoassemblies are assembled by a beta-cyclodextrin containing a positively charged host polymer and a hydrophobic guest polymer. The hydrophobic core of these types of assemblies serves as a nanocontainer to load and release the hydrophobic drugs, while the positively charged hydrophilic shell is able to condense the plasmid DNA and achieve its transfection/expression in osteoblast cells. These assemblies may be used as a new generation of multifunctional nanocarriers for simultaneous drug delivery and gene therapy.

References

Dec 4, 2001·Nature Biotechnology·A RebuffatS Rusconi
Feb 19, 2002·Chemical Reviews·Mikhail V. Rekharsky, Yoshihisa Inoue
Jan 25, 2003·Critical Care Medicine·Basilia ZingarelliHector R Wong
Sep 18, 2003·Bioconjugate Chemistry·Jianjun ChengMark E Davis
Jun 15, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Margit Maria Janát-AmsburySung Wan Kim
Sep 15, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Feng LiuLeaf Huang
Dec 2, 2004·Nature Reviews. Drug Discovery·Mark E Davis, Marcus E Brewster
Aug 20, 2005·Journal of Cellular Physiology·Lilian KastrupVictor Shahin
Nov 22, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kanjiro MiyataKazunori Kataoka
Mar 28, 2006·Biomaterials·Victor J ChenPeter X Ma
Nov 10, 2006·Advanced Drug Delivery Reviews·Vladimir P Torchilin
Feb 27, 2007·Nature Medicine·Zdravka MedarovaAnna Moore
Mar 1, 2007·Bioconjugate Chemistry·Derek W Bartlett, Mark E Davis
Mar 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jeremy D HeidelMark E Davis
Apr 7, 2007·Angewandte Chemie·William J RieterWenbin Lin
Jul 3, 2007·Journal of the American Chemical Society·Jason S KimWenbin Lin
Jun 24, 2008·Journal of the American Chemical Society·Maksym V YezhelyevXiaohu Gao
Feb 12, 2009·ACS Nano·Omid C Farokhzad, Robert Langer
Jun 25, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tontanai NumbenjaponAndrew Raubitschek

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Citations

May 30, 2013·Journal of Biomaterials Science. Polymer Edition·Yiyi WangYourong Duan
Nov 11, 2011·International Journal of Nanomedicine·Ling ZhangYuquan Wei
May 18, 2013·Advanced Drug Delivery Reviews·Koen RaemdonckStefaan C De Smedt
May 16, 2013·Advanced Drug Delivery Reviews·Jianxiang Zhang, Peter X Ma
Oct 14, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wei LiMingan Yu
Jun 20, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohammad Ariful IslamChong-Su Cho
Sep 18, 2012·Chemical Communications : Chem Comm·Huaping TanXiaohong Hu
Dec 27, 2015·Colloids and Surfaces. B, Biointerfaces·Chih-Yu KuoWen-Yen Chiu
Jan 12, 2013·Journal of Colloid and Interface Science·Yu WangJianxiang Zhang
Feb 27, 2015·Chemical Reviews·Guocan YuFeihe Huang
Jun 28, 2011·Trends in Biotechnology·Nilesh P IngleTheresa M Reineke
Dec 2, 2014·ACS Applied Materials & Interfaces·Jing-Jun NieFu-Jian Xu
Mar 26, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuxuan ZhuXiaohui Li
May 31, 2014·Analytical Chemistry·Bo YanVincent M Rotello
Aug 24, 2012·Macromolecular Rapid Communications·Firdaus YhayaMartina H Stenzel
Jan 27, 2011·Luminescence : the Journal of Biological and Chemical Luminescence·Zhuo Bin ShangWei Jun Jin
Jul 6, 2011·Macromolecular Bioscience·Véronique WintgensCatherine Amiel
Sep 4, 2012·Macromolecular Rapid Communications·Huaping TanDangsheng Xiong
Oct 13, 2010·Chemistry : a European Journal·Sabine Saint MartinCyril Aymonier
Jul 18, 2015·Chemistry : a European Journal·Laura Gallego-YergaJosé M García Fernández
Mar 23, 2012·Biomaterials·Peifeng LiuYourong Duan
Sep 20, 2012·International Journal of Pharmaceutics·Ling CheXiaohui Li
Feb 4, 2014·Acta Biomaterialia·Xing ZhouJianxiang Zhang
Jul 15, 2015·Nano Letters·Pawel W Majewski, Kevin G Yager
Jun 9, 2015·Chemical Communications : Chem Comm·Ping HuYu Liu
Jul 30, 2015·Biomaterials Science·Zhe YangXintao Shuai
Jul 30, 2015·Biomaterials Science·Ruijiao DongXinyuan Zhu
Nov 3, 2010·Chemical Society Reviews·Carmen Ortiz MelletJuan M Benito

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