Host Gut Motility Promotes Competitive Exclusion within a Model Intestinal Microbiota

PLoS Biology
Travis J WilesRaghuveer Parthasarathy


The gut microbiota is a complex consortium of microorganisms with the ability to influence important aspects of host health and development. Harnessing this "microbial organ" for biomedical applications requires clarifying the degree to which host and bacterial factors act alone or in combination to govern the stability of specific lineages. To address this issue, we combined bacteriological manipulation and light sheet fluorescence microscopy to monitor the dynamics of a defined two-species microbiota within a vertebrate gut. We observed that the interplay between each population and the gut environment produces distinct spatiotemporal patterns. As a consequence, one species dominates while the other experiences sudden drops in abundance that are well fit by a stochastic mathematical model. Modeling revealed that direct bacterial competition could only partially explain the observed phenomena, suggesting that a host factor is also important in shaping the community. We hypothesized the host determinant to be gut motility, and tested this mechanism by measuring colonization in hosts with enteric nervous system dysfunction due to a mutation in the ret locus, which in humans is associated with the intestinal motility disorder kno...Continue Reading


Apr 14, 2017·Cell Host & Microbe·Carolina TropiniJustin L Sonnenburg
Mar 2, 2018·Human Vaccines & Immunotherapeutics·Audrey Humphries, Adil Daud
Apr 25, 2018·Nature Reviews. Microbiology·Katerina V-A Johnson, Kevin R Foster
May 4, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Julia GanzRaghuveer Parthasarathy
Sep 29, 2017·Tissue Barriers·Tatiana TakiishiNiels Olsen Saraiva Câmara
Mar 24, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Carl D JohnsonAnkush Gosain
Sep 22, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Adam Rich
Nov 15, 2018·PloS One·Savannah L LoganRaghuveer Parthasarathy
Dec 25, 2018·ELife·Matthew JemielitaBonnie L Bassler
May 18, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Thomas C G BoschMargaret McFall-Ngai
Jun 18, 2019·Annual Review of Microbiology·Jennifer A TaylorNina R Salama
Dec 12, 2018·PLoS Biology·Catherine D RobinsonBrendan J M Bohannan
Jul 31, 2019·Journal of Bacteriology·Kylie J WattsBarbara I Kazmierczak
May 7, 2020·Proceedings. Biological Sciences·William Bernard PerryRaminta Kazlauskaite
Apr 14, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kenji KikuchiTakuji Ishikawa
Apr 30, 2017·Molecular Neurobiology·Alexios-Fotios A MentisGeorgios M Hadjigeorgiou
Oct 5, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Julia Ganz
Jun 17, 2020·Lab Animal·Keaton StagamanKaren Guillemin
Mar 30, 2018·Frontiers in Microbiology·Tanita WeinNils F Hülter
Dec 7, 2018·PLoS Computational Biology·Edouard A Hay, Raghuveer Parthasarathy
May 6, 2019·PLoS Computational Biology·Florence BanseptClaude Loverdo
Aug 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Yuuki Obata, Vassilis Pachnis
Jul 11, 2020·Proceedings of the National Academy of Sciences of the United States of America·Alexander KlimovichThomas C G Bosch
Apr 4, 2018·Proceedings of the National Academy of Sciences of the United States of America·Savannah L LoganRaghuveer Parthasarathy
Oct 26, 2018·The ISME Journal·Clotilde Bongrand, Edward G Ruby
Mar 20, 2019·Clinical and Translational Medicine·Jun GongRavi Salgia
Dec 30, 2018·Proceedings of the National Academy of Sciences of the United States of America·Nick Vallespir Lowery, Tristan Ursell
Nov 16, 2019·NPJ Biofilms and Microbiomes·Jagadish SankaranThorsten Wohland
Sep 10, 2019·Frontiers in Microbiology·Thomas RawsonMichael B Bonsall
Sep 10, 2019·Evolutionary Anthropology·Amy LuNoah Snyder-Mackler
Jul 23, 2020·MBio·Peter DeinesThomas C G Bosch
Sep 27, 2019·Frontiers in Immunology·Caitlin C Murdoch, John F Rawls
Aug 12, 2020·Journal of Bacteriology·Dhrubajyoti NagJeffrey H Withey


Jul 17, 1998·Nature·P B Rainey, M Travisano
May 29, 2000·Current Opinion in Genetics & Development·K Dooley, L I Zon
Nov 25, 2003·Theoretical Population Biology·Linda J S Allen, Edward J Allen
May 24, 2005·Nature Methods·Kyoung-Hee ChoiHerbert P Schweizer
Feb 6, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·T F Chan, L A Vese
Jul 4, 2008·Nature·Brett A Melbourne, Alan Hastings
Aug 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Steven D Allison, Jennifer B H Martiny
Nov 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hyun Jung KimRustem F Ismagilov
Apr 4, 2009·Nature Reviews. Immunology·June L Round, Sarkis K Mazmanian
Apr 8, 2009·Nature·Jeff GoreAlexander van Oudenaarden
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jonathan P CelliRama Bansil
Sep 3, 2010·Trends in Ecology & Evolution·Otso Ovaskainen, Baruch Meerson
Sep 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Les Dethlefsen, David A Relman
Dec 3, 2010·PLoS Computational Biology·Niels Klitgord, Daniel Segrè
Apr 8, 2011·The ISME Journal·Guus RoeselersJohn F Rawls
Apr 30, 2011·Science·S R CarpenterB Weidel
Jun 1, 2011·Genome Biology·J Gregory CaporasoRob Knight
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Knut DrescherRaymond E Goldstein
Sep 29, 2011·Methods in Cell Biology·Kathryn Milligan-MyhreCarol H Kim
Jun 8, 2012·Science·Jeremy K NicholsonSven Pettersson
Jul 7, 2012·Science·Marek Basler, John J Mekalanos
Jul 17, 2012·Nature Reviews. Microbiology·Karoline Faust, Jeroen Raes
Sep 18, 2012·Cell Host & Microbe·Ivana SemovaJohn F Rawls
Sep 18, 2012·The Biological Bulletin·Michael J TaorminaKaren Guillemin
Oct 3, 2012·PLoS Computational Biology·Jonathan Friedman, Eric J Alm
Dec 18, 2012·Immunology·Trevor D Lawley, Alan W Walker
Feb 6, 2013·Gastroenterology·Purna C KashyapJustin L Sonnenburg
Jul 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Roie Levy, Elhanan Borenstein
Nov 19, 2013·Cell Host & Microbe·Tyler C CullenderRuth E Ley
Mar 13, 2014·Trends in Microbiology·Afrah ShafquatCurtis Huttenhower
Aug 26, 2014·Genome Biology·Lawrence A DavidEric J Alm
Aug 26, 2014·The ISME Journal·Pål TrosvikNils Christian Stenseth
Feb 24, 2015·The ISME Journal·Vanessa A VaraljayMary Ann Moran
May 7, 2015·Current Opinion in Pediatrics·Ankush Gosain, Adam S Brinkman

Related Concepts

Vibrio cholerae
Cell Motility
Immunofluorescence Microscopy
Ocular Motility Disorders

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Related Papers

Current Opinion in Clinical Nutrition and Metabolic Care
Christina E West
Cellular and Molecular Life Sciences : CMLS
Philippe Gérard
© 2020 Meta ULC. All rights reserved