Host immune response in returning travellers infected with malaria.

Malaria Journal
Gregory MacMullinDylan R Pillai

Abstract

Clinical observations suggest that Canadian-born (CB) travellers are prone to more severe malaria, characterized by higher parasite density in the blood, and severe symptoms, such as cerebral malaria and renal failure, than foreign-born travellers (FB) from areas of malaria endemicity. It was hypothesized that host cytokine and chemokine responses differ significantly in CB versus FB patients returning with malaria, contributing to the courses of severity. A more detailed understanding of the profiles of cytokines, chemokines, and endothelial activation may be useful in developing biomarkers and novel therapeutic approaches for malaria. The patient population for the study (n = 186) was comprised of travellers returning to Toronto, Canada between 2007 and 2011. The patient blood samples' cytokine, chemokine and angiopoietin concentrations were determined using cytokine multiplex assays, and ELISA assays. Significantly higher plasma cytokine levels of IL-12 (p40) were observed in CB compared to FB travellers, while epidermal growth factor (EGF) was observed to be higher in FB than CB travellers. Older travellers (55 years old or greater) with Plasmodium vivax infections had significantly higher mean cytokine levels for IL-6 and ...Continue Reading

References

Aug 15, 1990·Annals of Internal Medicine·A E Greenberg, H O Lobel
Dec 1, 1989·Biochemical Society Transactions·J A LovegroveV Marks
Nov 14, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K Marsh, R W Snow
May 23, 1998·The American Journal of Tropical Medicine and Hygiene·C R NewtonR O Whitten
Jul 11, 1998·Infectious Disease Clinics of North America·K C Kain, J S Keystone
Nov 7, 1999·Chemical Immunology·L GuB J Rollins
Jun 17, 2000·Infection and Immunity·A J LutyP G Kremsner
Feb 15, 2002·Tissue Antigens·F AguilarA Núñez-Roldán
Jul 19, 2002·Archives of Internal Medicine·Enrique CasalinoElisabeth Bouvet
Nov 5, 2002·Clinical and Diagnostic Laboratory Immunology·Iñigo Angulo, Manuel Fresno
Apr 20, 2004·International Journal of Radiation Oncology, Biology, Physics·Wai-Man SzeKuen Chan
May 15, 2004·International Journal of Radiation Oncology, Biology, Physics·Roy S Herbst
Oct 16, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Karin LederJoseph Torresi
Oct 19, 2006·Trends in Immunology·Ulrike Fiedler, Hellmut G Augustin
Aug 23, 2007·Journal of Intensive Care Medicine·Ramesh Venkataraman, John A Kellum
Apr 17, 2008·Human Molecular Genetics·Sandrine MarquetAlain J Dessein
Oct 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tsin W YeoNicholas M Anstey
Apr 8, 2009·Trends in Parasitology·Nicholas M AnsteyRic N Price
May 19, 2009·Angiogenesis·Markus Thomas, Hellmut G Augustin
Jan 15, 2010·Malaria Journal·Bruno B AndradeManoel Barral-Netto
Jun 22, 2010·PLoS Medicine·Simon I HayRobert W Snow
Jan 20, 2011·Infection and Immunity·Craig N MorrellBarbara Detrick

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Citations

Sep 3, 2013·Asian Pacific Journal of Tropical Biomedicine·Chuchard Punsawad
Sep 4, 2014·Memórias do Instituto Oswaldo Cruz·Leonardo José de Moura CarvalhoYuri Chaves Martins
May 7, 2016·Circulation Research·Anthony O EtyangJ Anthony G Scott
Mar 27, 2020·American Journal of Hypertension·Chukwuemeka R NwokochaAnthony B Ebeigbe
May 10, 2018·Frontiers in Immunology·Aleksandra LeligdowiczKevin C Kain
Feb 4, 2016·Tropical Diseases, Travel Medicine and Vaccines·N AllenS P Kennelly

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Methods Mentioned

BETA
PCR
Assay
ELISA

Software Mentioned

GraphPad Prism

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