Host immunity as a determinant of treatment outcome in Plasmodium falciparum malaria

The Lancet Infectious Diseases
Stephen J RogersonSteven R Meshnick

Abstract

Host immunity is an important but poorly understood determinant of antimalarial efficacy, influencing the outcome of prevention and treatment trials. Variations in host immunity might explain why factors such as host genetics, age, pregnancy, infection with HIV, parasite density, and malaria transmission intensity, can raise or lower apparent cure rates. Recently, attempts have been made to characterise immunological correlates of treatment outcome in Plasmodium falciparum malaria, but not yet for Plasmodium vivax. A better understanding of such correlates might improve trials of antimalarial drugs and provide leads for vaccine development. Greater understanding of the relation between host immunity and treatment outcome is crucial to making informed choices about the use of safe but partly effective drugs for malaria prevention in children and pregnant women. With increasing malaria control efforts worldwide, declining population immunity might alter drug response profiles. Improved methods for assessing antimalarial immunity will strengthen malaria control efforts.

References

Sep 1, 1977·Clinical Allergy·F CarswellP S Harland
Sep 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·R W SnowB M Greenwood
Jan 1, 1991·Pharmacology & Therapeutics·W H Wernsdorfer, D Payne
May 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·A Björkman, P A Phillips-Howard
May 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·O Müller, R Moser
May 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·K MarshB M Greenwood
May 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·M R HollingdaleA Bjorkmann
Jul 2, 1988·BMJ : British Medical Journal·O O SimooyaA F Fleming
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·I C Bygbjerg, H Flachs
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·A M Bradley-MooreB R Kirkwood
Mar 25, 1967·British Medical Journal·G M Edington
Jan 1, 1980·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J MurrayC J Murray
Nov 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·F O ter KuileN J White
Feb 1, 1997·The Journal of Antimicrobial Chemotherapy·D ZakulaR C Goldman
Dec 23, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·H EkvallA Björkman
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·T SmithH P Beck
Apr 14, 2000·The Journal of Infectious Diseases·R HutagalungV R Gordeuk
Jul 29, 2000·The Journal of Infectious Diseases·K ChotivanichN J White
Feb 15, 2001·The New England Journal of Medicine·A DjimdéC V Plowe
Feb 15, 2001·The New England Journal of Medicine·D C Warhurst
Mar 10, 2001·Parasite Immunology·E M RileyK A Koram
Mar 17, 2001·Tropical Medicine & International Health : TM & IH·F P MockenhauptU Bienzle
Mar 31, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·M R KamyaP J Rosenthal
May 18, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·M MayxayN J White
Jul 31, 2001·European Journal of Clinical Nutrition·F H VerhoeffR L Broadhead
Mar 19, 2002·Antimicrobial Agents and Chemotherapy·Paul N NewtonNicholas J White
Apr 9, 2002·The Lancet Infectious Diseases·Chansuda WongsrichanalaiSteven R Meshnick
Apr 16, 2002·The Korean Journal of Parasitology·Udomsak SilachamroonSornchai Looareesuwan
May 23, 2002·Journal of Tropical Pediatrics·J L DeenL von Seidlein
Sep 24, 2002·Medical and Veterinary Entomology·J C Koella, F L Sørense

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Citations

Jul 4, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ilse C E HendriksenArjen M Dondorp
Nov 28, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Freya J I FowkesJames G Beeson
Sep 12, 2012·The Journal of Infectious Diseases·Freya J I FowkesJames G Beeson
Nov 19, 2010·Proceedings. Biological Sciences·Tiago Antao, Ian M Hastings
Mar 29, 2012·BMJ : British Medical Journal·Anna M CheckleyChristopher J M Whitty
Aug 27, 2011·Malaria Journal·Mahamadou DiakiteLisa C Ranford-Cartwright
Nov 16, 2010·Future Microbiology·Timothy M E DavisStephen J Rogerson
Dec 15, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Clara MenéndezAlfredo Mayor
Feb 14, 2012·Future Microbiology·Georges Emile Raymond Grau, Alister Gordon Craig
Oct 9, 2012·Trends in Parasitology·Christian R EngwerdaJames S McCarthy
Jun 28, 2011·The Lancet Infectious Diseases·Clara FlateauGilles Pialoux
May 24, 2012·Pediatric Blood & Cancer·Peter AkaSam M Mbulaiteye
Jun 2, 2011·International Journal of Cancer. Journal International Du Cancer·Mercy Guech-OngeySam M Mbulaiteye
Nov 29, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Steve M TaylorSteven R Meshnick
Jun 21, 2016·Expert Review of Anti-infective Therapy·Brioni R MooreTimothy M E Davis
Sep 11, 2016·FEMS Microbiology Reviews·Charles J Woodrow, Nicholas J White
Feb 22, 2012·Expert Review of Anti-infective Therapy·Raquel GonzálezAlfredo Mayor
Apr 6, 2016·Antimicrobial Agents and Chemotherapy·James S McCarthyJörg J Möhrle
Aug 5, 2015·Antimicrobial Agents and Chemotherapy·Ian M HastingsEva Maria Hodel
Jul 2, 2014·Antimicrobial Agents and Chemotherapy·Katherine KayIan M Hastings
Sep 22, 2017·The Journal of Infectious Diseases·Ricardo AtaídeFreya J I Fowkes
Dec 6, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Shirin HeidariElly Katabira
Mar 20, 2018·Emerging Infectious Diseases·Mie IkedaToshihiro Mita
Nov 21, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ritah F MutagondaEleni Aklillu
Feb 23, 2013·Japanese Journal of Infectious Diseases·Futoshi HigaJiro Fujita

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