Host Lipid Mediators in Leprosy: The Hypothesized Contributions to Pathogenesis

Frontiers in Immunology
Carlos A M Silva, John T Belisle

Abstract

The spectrum of clinical forms observed in leprosy and its pathogenesis are dictated by the host's immune response against Mycobacterium leprae, the etiological agent of leprosy. Previous results, based on metabolomics studies, demonstrated a strong relationship between clinical manifestations of leprosy and alterations in the metabolism of ω3 and ω6 polyunsaturated fatty acids (PUFAs), and the diverse set of lipid mediators derived from PUFAs. PUFA-derived lipid mediators provide multiple functions during acute inflammation, and some lipid mediators are able to induce both pro- and anti-inflammatory responses as determined by the cell surface receptors being expressed, as well as the cell type expressing the receptors. However, little is known about how these compounds influence cellular immune activities during chronic granulomatous infectious diseases, such as leprosy. Current evidence suggests that specialized pro-resolving lipid mediators (SPMs) are involved in the down-modulation of the innate and adaptive immune response against M. leprae and that alteration in the homeostasis of pro-inflammatory lipid mediators versus SPMs is associated with dramatic shifts in the pathogenesis of leprosy. In this review, we discuss the ...Continue Reading

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Citations

Nov 13, 2019·Expert Opinion on Therapeutic Targets·Pei ShangJiachun Feng
Jan 11, 2020·Frontiers in Immunology·Émilie Doz-DeblauweNathalie Winter
Jul 1, 2019·BMJ Case Reports·Christopher Michael Logas, Kathryn B Holloway
Feb 13, 2021·Proteomes·Sakshi GautamDeepa Bisht

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