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Host MHC class I gene control of NK-cell specificity in the mouse

Immunological Reviews

Feb 1, 1997

P HöglundKlas Kärre

Abstract

The missing self model predicts that NK cells adapt somatically to the type as well as levels of MHC class I products expressed by their host. Transgenic and gene knock-out mice have provided conclusive evidence that MHC class I genes control specificity and tolerance of NK cells. The a...read more

Mentioned in this Paper

Clonal Anergy
LY-49 receptor
Neoplasms
KLRA1 wt Allele
Receptor Expression
Clone
Genes, H-2 Class I
Genes, MHC Class I
Mice, Knockout
H-2 Antigens
Paper Details
References
  • References65
  • Citations62
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  • References65
  • Citations62
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Host MHC class I gene control of NK-cell specificity in the mouse

Immunological Reviews

Feb 1, 1997

P HöglundKlas Kärre

PMID: 9059879

DOI: 10.1111/j.1600-065x.1997.tb00936.x

Abstract

The missing self model predicts that NK cells adapt somatically to the type as well as levels of MHC class I products expressed by their host. Transgenic and gene knock-out mice have provided conclusive evidence that MHC class I genes control specificity and tolerance of NK cells. The a...read more

Mentioned in this Paper

Clonal Anergy
LY-49 receptor
Neoplasms
KLRA1 wt Allele
Receptor Expression
Clone
Genes, H-2 Class I
Genes, MHC Class I
Mice, Knockout
H-2 Antigens

Similar Papers Found In These Feeds

NK Cells

NK cells identify and attack target cells based on integration of signals from activation and inhibitory receptors, whose ligands exhibit complex expression and/or binding patterns. Here is the latest research.


Reviews in Immunology

Discover the latest reviews in immunology research in this collection of the top immunology review journals.

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The Ly-49 family: genes, proteins and recognition of class I MHC

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Paper Details
References
  • References65
  • Citations62
12345...
  • References65
  • Citations62
12345...
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