PMID: 9187232Apr 1, 1997Paper

Host-microbe interaction in HLA-B27-associated diseases

Annals of Medicine
K Granfors

Abstract

The mechanisms leading to the development of HLA-B27-associated diseases, spondyloarthropathies, are unknown. One of them, reactive arthritis, is clearly caused by an infection, and joint inflammation develops soon after or during an infection elsewhere in the body. In other forms of spondyloarthropathies, such as ankylosing spondylitis, association with infection is suggested but it is not as clear. Pathogenetic mechanisms of reactive arthritis are a focus of great interest as causative infections and strong genetic association are known. How HLA-B27 determines the appearance of joint complications after certain infections is not clear. Several theories have been proposed to explain the association, and they usually include the idea that interaction between microbe and host is abnormal and inefficient in HLA-B27-positive subjects in whom reactive arthritis develops.

References

Oct 1, 1979·Journal of Oral Rehabilitation·P Kirveskari
May 2, 1992·Lancet·O Mäki-Ikola, K Granfors
Feb 1, 1991·Annals of the Rheumatic Diseases·R Merilahti-PaloA Toivanen
Jan 26, 1989·The New England Journal of Medicine·K GranforsA Toivanen
Jun 1, 1989·The Journal of Infectious Diseases·K GranforsD T Yu
Dec 1, 1989·Molecular Microbiology·B B Finlay, S Falkow
Mar 1, 1988·Infection·J A Hoogkamp-KorstanjeJ Heesemann
Jul 1, 1986·Annals of the Rheumatic Diseases·K Granfors, A Toivanen
Apr 28, 1973·Lancet·D A BrewertonR D Sturrock
Sep 1, 1974·Arthritis and Rheumatism·K AhoA Tiilikainen
Apr 5, 1973·The New England Journal of Medicine·L SchlossteinC M Pearson
Jan 1, 1969·Acta Rheumatologica Scandinavica·P AhvonenK Aho
Apr 1, 1983·Annals of the Rheumatic Diseases·R LeinoA Toivanen
Jan 1, 1995·Annual Review of Immunology·G R BurmesterN Wolf
Dec 1, 1993·Infection and Immunity·M WuorelaK Granfors
Jul 1, 1994·Current Opinion in Rheumatology·R D Inman, R H Scofield
May 1, 1994·Arthritis and Rheumatism·H SahlyU Ullmann
May 1, 1996·Diseases of the Colon and Rectum·P GiordanoJ R Monson
Apr 1, 1996·Arthritis and Rheumatism·T HayashiH E Jasin
Jan 1, 1996·Immunology Today·T E FeltkampJ A Lopez de Castro
Jan 1, 1997·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·P Kirveskari

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Citations

Apr 2, 2008·Internal Medicine·Tomohiro KogaKiyoshi Migita
Jan 5, 2010·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Yuki NankeShigeru Kotake
Nov 5, 2010·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Yuki NankeShigeru Kotake
Feb 3, 1999·Baillière's Clinical Rheumatology·L KoehlerA P Hudson

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