Host-microbiota interactions in inflammatory bowel disease.

Gut Microbes
Charles O Elson, Yingzi Cong

Abstract

The interaction of the host with its abundant intestinal microbiota is complex and engages most of the cells in the intestinal mucosa. The inflammatory bowel diseases appear to be disorders of the host immune response to the microbiota. This is supported by data from induced gene mutations in mice and more recently by the identification of gene variants in humans that result in IBD or IBD susceptibility. These genetic studies have provided insights into the cells and molecular pathways involved in the host-microbiota dialog. This review discusses the innate, adaptive, and regulatory immune response to the microbiota in the context of the mouse and human genes that are involved in maintaining intestinal homeostasis and preventing inflammation. These data continue to support the hypothesis that inflammatory bowel disease results from a dysregulated adaptive immune response, particularly a CD4 T-cell response, to the microbiota. The microbiota itself is an active participant in these homeostatic processes. The microbiota composition is perturbed during inflammation, resulting in a dysbiosis that may induce or perpetuate inflammation. However, host genotype and the environment have a major impact on the shape of such dysbiosis, as ...Continue Reading

References

Dec 31, 1997·The Journal of Experimental Medicine·A MizoguchiA K Bhan
May 8, 2002·The Journal of Experimental Medicine·M F NeurathR S Blumberg
Feb 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Thomas WelteXin-Yuan Fu
Aug 10, 2004·Gastroenterology·Arlette Darfeuille-MichaudJean-Frédéric Colombel
Nov 13, 2004·The New England Journal of Medicine·Peter J MannonUNKNOWN Anti-IL-12 Crohn's Disease Study Group
May 4, 2006·The Journal of Clinical Investigation·David YenDonna Rennick
Jul 13, 2006·Gastroenterology·Maria Van der SluisAlexandra W C Einerhand
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Holm H UhligFiona Powrie
Mar 16, 2007·Nature·Arianna NenciManolis Pasparakis
May 9, 2007·Nature Immunology·Eva V Acosta-RodriguezGiorgio Napolitani
Jun 15, 2007·Inflammatory Bowel Diseases·Jishu Shi
Jun 16, 2007·Gastroenterology·Charles O ElsonRobert A Kastelein
Jul 20, 2007·The Journal of Experimental Medicine·Francesco AnnunziatoSergio Romagnani
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Daniel N FrankNorman R Pace
Oct 19, 2007·Nature·Peter J TurnbaughJeffrey I Gordon
Nov 17, 2007·Cell Host & Microbe·Daniel A PetersonJeffrey I Gordon
Nov 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Matija HedlClara Abraham
Feb 13, 2008·The Journal of Experimental Medicine·Emre E TurerAveril Ma
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daisuke FujiwaraJonathan Braun
May 27, 2008·Nature Reviews. Immunology·Judy H Cho

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Citations

Dec 20, 2013·Journal of Developmental Origins of Health and Disease·M Weng, W A Walker
Mar 4, 2014·Inflammatory Bowel Diseases·Michael DavenportP'ng Loke
Dec 5, 2012·Current Opinion in Gastroenterology·Elke Cario
Feb 26, 2016·Frontiers in Veterinary Science·Rosario Galarza-SeeberGuillermo Tellez
Apr 1, 2014·FEBS Letters·Calum J WalshPaul D Cotter
Jun 14, 2015·Journal of Crohn's & Colitis·Lucy C HicksHorace R T Williams
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Lili DingWendong Huang
Jan 15, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Valeria D'Argenio, Francesco Salvatore
Jul 16, 2013·Journal of Digestive Diseases·Cheng Gong Yu, Qin Huang
Apr 1, 2014·Cell·Yasmine Belkaid, Timothy W Hand
May 15, 2015·Journal of Immunology Research·Linlin ChenJunwen Yang
Jun 19, 2013·Best Practice & Research. Clinical Gastroenterology·Corina CeapaRaish Oozeer
Jan 1, 2014·Frontiers in Veterinary Science·Guillermo Tellez
Apr 9, 2016·Inflammatory Bowel Diseases·Wei WuYingzi Cong
Aug 1, 2015·PloS One·Heather L Evans-MarinYingzi Cong
Aug 20, 2015·Nutrients·María Carmen CenitYolanda Sanz
Aug 9, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Hilal Ahmad, Vijay L Kumar
Nov 14, 2018·Intestinal research·Prisca Yue Min HoWan Chee Ong
Jan 7, 2015·World Journal of Gastroenterology : WJG·Lin-Jing LiBai-Sui Feng
Jul 26, 2017·World Journal of Gastroenterology : WJG·Francesca Romana PonzianiAntonio Gasbarrini
Mar 10, 2020·GigaScience·Edi PriftiJean-Daniel Zucker
Aug 3, 2017·Mucosal Immunology·E V Russler-GermainC-S Hsieh
Feb 6, 2020·Nature Reviews. Immunology·Kang ChenAndrea Cerutti
Jan 21, 2017·BMC Bioinformatics·Séverine AffeldtJean-Daniel Zucker
Mar 7, 2021·Pathogens·Martina FranzinGabriele Stocco

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