Oct 18, 2018

Host NAD+ metabolism and infections: therapeutic implications

International Immunology
Amit Singhal, Catherine Youting Cheng

Abstract

Nicotinamide adenine dinucleotide (NAD+) is both a crucial coenzyme and a cosubstrate for various metabolic reactions in all living cells. Maintenance of NAD+ levels is essential for cell energy homeostasis, survival, proliferation and function. Mounting evidence points to NAD+ as one of the major modulators of immuno-metabolic circuits, thus regulating immune responses and functions. Recent studies delineate impaired host NAD+ metabolism during chronic infections and inflammation, suggesting NAD+ replenishment as an avenue to ameliorate deleterious inflammatory responses. Here, we discuss aspects of NAD+ biosynthesis and consumption, NAD+ biology during infections and how NAD+ metabolism can be intervened with pharmacologically to enhance the host's immunological fitness against pathogens.

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Mentioned in this Paper

Metabolic Process, Cellular
Study
Immune Response
Protein kinase modulator
Cell Proliferation
Metabolic Pathway
Inflammation
NAD Metabolic Process
Energy Homeostasis
Nicotinamide adenine dinucleotide (NAD)

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