Host-parasite interactions that guide red blood cell invasion by malaria parasites

Current Opinion in Hematology
Aditya S PaulManoj Theodore Duraisingh

Abstract

Malaria is caused by the infection and proliferation of parasites from the genus Plasmodium in red blood cells (RBCs). A free Plasmodium parasite, or merozoite, released from an infected RBC must invade another RBC host cell to sustain a blood-stage infection. Here, we review recent advances on RBC invasion by Plasmodium merozoites, focusing on specific molecular interactions between host and parasite. Recent work highlights the central role of host-parasite interactions at virtually every stage of RBC invasion by merozoites. Biophysical experiments have for the first time measured the strength of merozoite-RBC attachment during invasion. For P. falciparum, there have been many key insights regarding the invasion ligand PfRh5 in particular, including its influence on host species tropism, a co-crystal structure with its RBC receptor basigin, and its suitability as a vaccine target. For P. vivax, researchers identified the origin and emergence of the parasite from Africa, demonstrating a natural link to the Duffy-negative RBC variant in African populations. For the simian parasite P. knowlesi, zoonotic invasion into human cells is linked to RBC age, which has implications for parasitemia during an infection and thus malaria. New...Continue Reading

References

Feb 28, 1975·Science·J A DvorakT Shiroishi
May 1, 1988·The Journal of Cell Biology·T Y Sam-YelloweM E Perkins
Dec 31, 2003·Molecular and Biochemical Parasitology·Julian C RaynerJohn W Barnwell
Oct 28, 2008·International Journal for Parasitology·Paul R Gilson, Brendan S Crabb
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Didier MénardPeter A Zimmerman
Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Wai-Hong ThamAlan F Cowman
Oct 21, 2010·The Journal of Infectious Diseases·Amy K BeiManoj T Duraisingh
Jul 12, 2011·Nature Structural & Molecular Biology·Joseph D BatchelorNiraj H Tolia
Jul 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Prakash SrinivasanLouis H Miller
Dec 20, 2011·Trends in Parasitology·Wai-Hong ThamAlan F Cowman
Jun 20, 2012·International Journal for Parasitology·Katherine L HarveyBrendan S Crabb
Sep 19, 2012·The Journal of Cell Biology·Alan F CowmanJake Baum
Dec 26, 2012·Proceedings of the National Academy of Sciences of the United States of America·Robert W MoonMichael J Blackman
Jan 12, 2013·Molecular and Biochemical Parasitology·Karen HaytonThomas E Wellems
Feb 7, 2013·Advances in Parasitology·Peter A ZimmermanOdile Mercereau-Puijalon
Mar 29, 2013·Nature Communications·Caeul LimManoj T Duraisingh
Jul 31, 2013·Current Opinion in Microbiology·Pushkar Sharma, Chetan E Chitnis
Nov 28, 2013·Nature Communications·Xiaohong GaoPeter R Preiser
Dec 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Madushi WanaguruGavin J Wright
Jan 15, 2014·PLoS Pathogens·Joseph D BatchelorNiraj H Tolia
Feb 11, 2014·Cellular Microbiology·Christof GrüringManoj T Duraisingh
Feb 22, 2014·Nature Communications·Weimin LiuPaul M Sharp
Mar 22, 2014·PLoS Pathogens·Gavin J Wright, Julian C Rayner
Jun 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Prakash SrinivasanLouis H Miller
Jul 6, 2014·Biophysical Journal·Sabyasachi DasguptaGerhard Gompper
Aug 1, 2014·Science Translational Medicine·Faith H OsierKevin Marsh

❮ Previous
Next ❯

Citations

Dec 31, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jakub GruszczykWai-Hong Tham
Jul 23, 2016·Parasitology International·Agata ZerkaEwa Jaskiewicz
Mar 18, 2017·Current Opinion in Hematology·Aditi AlagananChetan E Chitnis
Aug 18, 2018·Pediatric Blood & Cancer·Jan Palmblad, Petter Höglund
Aug 5, 2017·Nature Reviews. Disease Primers·Margaret A PhillipsTimothy N C Wells
Aug 31, 2019·Cellular Microbiology·Li-Jin ChanWai-Hong Tham
Feb 19, 2017·Cold Spring Harbor Perspectives in Medicine·Caeul LimManoj T Duraisingh
Jun 17, 2020·Cellular & Molecular Immunology·Stephen TukwasibweFrancesco Colucci
Apr 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Marion KochJake Baum
Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Usheer KanjeeManoj T Duraisingh
Jun 27, 2019·Malaria Journal·Priscilla D S VenturaMarcos L Gazarini
Feb 23, 2020·Seminars in Immunopathology·Mathias SchmalerClaudia Daubenberger
May 16, 2020·Journal of Parasitology Research·Ayenew AddisuAyalew Jejaw Zeleke
Mar 4, 2021·Journal of Blood Medicine·Nelly Al AudhahLoeki Enggar Fitri
Jul 28, 2020·Biochimie·Pushpa MishraShobhona Sharma
Dec 29, 2020·Molecular Microbiology·Rouaa Ben ChaabeneDominique Soldati-Favre
Jul 4, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Dhaneswar PrustyVijay Kumar Prajapati

❮ Previous
Next ❯

Methods Mentioned

BETA
optical tweezers

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.