Host-Pathogen Interactions Mediated by MDR Transporters in Fungi: As Pleiotropic as it Gets!

Genes
Mafalda CavalheiroMiguel C Teixeira

Abstract

Fungal infections caused by Candida, Aspergillus, and Cryptococcus species are an increasing problem worldwide, associated with very high mortality rates. The successful prevalence of these human pathogens is due to their ability to thrive in stressful host niche colonization sites, to tolerate host immune system-induced stress, and to resist antifungal drugs. This review focuses on the key role played by multidrug resistance (MDR) transporters, belonging to the ATP-binding cassette (ABC), and the major facilitator superfamilies (MFS), in mediating fungal resistance to pathogenesis-related stresses. These clearly include the extrusion of antifungal drugs, with C. albicans CDR1 and MDR1 genes, and corresponding homologs in other fungal pathogens, playing a key role in this phenomenon. More recently, however, clues on the transcriptional regulation and physiological roles of MDR transporters, including the transport of lipids, ions, and small metabolites, have emerged, linking these transporters to important pathogenesis features, such as resistance to host niche environments, biofilm formation, immune system evasion, and virulence. The wider view of the activity of MDR transporters provided in this review highlights their releva...Continue Reading

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Citations

Aug 28, 2019·Nature Structural & Molecular Biology·Sriram Srikant, Rachelle Gaudet
Apr 25, 2019·Scientific Reports·Eliandro Reis TavaresSueli Fumie Yamada-Ogatta
Mar 3, 2020·Frontiers in Cellular and Infection Microbiology·Rui SantosMiguel C Teixeira
Mar 12, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Daniel Clemente de MoraesAntônio Ferreira-Pereira
Feb 24, 2019·Journal of Fungi·Jehoshua SharmaRebecca S Shapiro
Feb 13, 2021·International Journal of Molecular Sciences·Mafalda CavalheiroMiguel C Teixeira
Sep 24, 2021·Current Drug Targets·Sweety DahiyaAnil K Chhillar

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